Close

We use cookies to improve your experience of our website. Privacy Policy

Skip to main content

Institute of Applied Data Science

Search
Menu

Professor Claude Chelala

Claude Chelala

Professor of Bioinformatics

Faculty of Medicine and Dentistry
Barts Cancer Institute
+44 20 7882 3570

www.bci.qmul.ac.uk/en/staff/item/claude-chelala-2

Research

pancreatic cancer (PED), breast cancer (BCCTBbp), next-generation sequencing, array data analysis/integration

Interests

My research is very collaborative with clinical and basic scientists at the SMD and BCI.

An important aspect of my research work involves designing and setting up platforms and tools for the organisation, integration and mining of complex –omics data sets.

Current work covers pancreatic cancer (PED) and breast cancer (BCCTBbp). Both platforms are developed as built-in accompaniment to clinical tissue banks to maximise research output.

A closely related platform is being implemented to host the SEARCHBreast data relating to in vivo models of breast cancer. I also have designed and implemented the SNPnexus tool, which offers a better understanding and interpretation of the functional role of genetic variations in the sequenced genomes.

I am interested in studying the Field cancerisation in breast cancer working very closely with Prof Louise Jones. We are collecting samples of apparently normal tissue from set distances away from a breast cancer in order to generate signatures that identify morphologically normal but genetically altered breast tissue that could be applied for more tailored therapy (ensuring excision of genetically altered tissue at surgery), risk assessment and early detection. This project will use high-throughput sequencing and computational genomics applied to a unique cohort of patient tissue samples.

In addition, my computational work covers large-scale analysis of common/specific alteration signatures in human cancers in order to identify cancer-causing genes, -related molecular pathways as well as new biomarkers for novel diagnostics or screening in cancer.

With Prof Conrad Bessant, I co-lead the computational biology theme for the new Life Science Initiative (LSI) at QMUL to facilitate the development of a state-of-the-art computational biology research at LSI.

Publications

Publications of specific relevance to Applied Data Science

2021

Sivapalan L, Kocher HM, Ross-Adams H and Chelala C (2021). Molecular profiling of ctDNA in pancreatic cancer: Opportunities and challenges for clinical application. Pancreatology  vol. 21, (2) 363-378. 10.1016/j.pan.2020.12.017

2020

Gadaleta E, Fourgoux P, Pirró S, Thorn GJ, Nelan R, Ironside A, Rajeeve V, Cutillas PR, Lobley AE, Wang J, Gea E, Ross-Adams H, Bessant C, Lemoine NR, Jones LJ and Chelala C (2020). Characterization of four subtypes in morphologically normal tissue excised proximal and distal to breast cancer. Npj Breast Cancer  vol. 6, (1) 10.1038/s41523-020-00182-9
Montero Melendez T, Nagano A, Chelala C, Filer A, Buckley CD and Perretti M (2020). Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis. Nature Research (Part of Springer Nature)  Nature Communications  vol. 11, (1) 10.1038/s41467-020-14421-x
Lu S, Zhang Z, Du P, Chard LS, Yan W, Khouri ME, Wang Z, Chu Y, Gao D, Zhang Q, Zhang L, Nagano A, Wang J, Chelala C, Liu J, Chen J, Liu P, Dong Y, Wang S, Li X, Dong J, Lemoine NR, Pei D and Wang Y (2020). A virus-infected, reprogrammed somatic cell–derived tumor cell (VIREST) vaccination regime can prevent initiation and progression of pancreatic cancer. Clinical Cancer Research  vol. 26, (2) 465-476. 10.1158/1078-0432.CCR-19-1395

2019

Pirrò S, Spada F, Gadaleta E, Ferrentino F, Thorn GJ, Cesareni G and Chelala C (2019). HiPPO and PANDA: Two Bioinformatics Tools to Support Analysis of Mass Cytometry Data. J Comput Biol  10.1089/cmb.2019.0384
Pirrò S, Gadaleta E, Galgani A, Colizzi V and Chelala C (2019). SMAC, a computational system to link literature, biomedical and expression data. Scientific Reports  vol. 9, (1) 10.1038/s41598-019-47046-2
Reader CS, Vallath S, Steele CW, Haider S, Brentnall A, Desai A, Moore KM, Jamieson NB, Chang D, Bailey P, Scarpa A, Lawlor R, Chelala C, Keyse SM, Biankin A, Morton JP, Evans TJ, Barry ST, Sansom OJ, Kocher HM and Marshall JF (2019). The integrin αvβ6 drives pancreatic cancer through diverse mechanisms and represents an effective target for therapy. Journal of Pathology  vol. 249, (3) 332-342. 10.1002/path.5320
Martin S (2019). MLH1 deficiency leads to deregulated mitochondrial metabolism. Nature Publishing Group  Cell Death and Disease  vol. 10, 795-795. 10.1038/s41419-019-2018-y
Barry S, Carlsen E, Marques P, Stiles CE, Gadaleta E, Berney DM, Roncaroli F, Chelala C, Solomou A, Herincs M, Caimari F, Grossman AB, Crnogorac-Jurcevic T, Haworth O, Gaston-Massuet C and Korbonits M (2019). Tumor microenvironment defines the invasive phenotype of AIP-mutation-positive pituitary tumors. Oncogene  vol. 38, (27) 5381-5395. 10.1038/s41388-019-0779-5
Araf S, Wang J, Korfi K, Pangault C, Kotsiou E, Rio-Machin A, Rahim T, Heward J, Clear A, Iqbal S, Davies JK, Johnson P, Calaminici M, Montoto S, Auer R, Chelala C, Gribben JG, Graham TA, Fest T, Fitzgibbon J and Okosun J (2019). Correction: Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma (Leukemia, (2018), 32, 5, (1261-1265), 10.1038/s41375-018-0043-y). Leukemia  vol. 33, (6) 10.1038/s41375-019-0425-9

2018

(2018). MicroRNA and transcriptome analysis in periocular Sebaceous Gland Carcinoma. Scientific Reports  vol. 8, (1) 10.1038/s41598-018-25900-z
Inman GJ, Wang J, Nagano A, Alexandrov LB, Purdie KJ, Taylor RG, Sherwood V, Thomson J, Hogan S, Spender LC, South AP, Stratton M, Chelala C, Harwood CA, Proby CM and Leigh IM (2018). The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature. Nature Communications  vol. 9, (1) 10.1038/s41467-018-06027-1
Arnandis T, Monteiro P, Adams SD, Bridgeman VL, Rajeeve V, Gadaleta E, Marzec J, Chelala C, Malanchi I, Cutillas PR and Godinho SA (2018). Oxidative Stress in Cells with Extra Centrosomes Drives Non-Cell-Autonomous Invasion. Developmental Cell  vol. 47, (4) 409-424.e9. 10.1016/j.devcel.2018.10.026
Dayem Ullah AZ, Oscanoa J, Wang J, Nagano A, Lemoine NR and Chelala C (2018). SNPnexus: Assessing the functional relevance of genetic variation to facilitate the promise of precision medicine. Nucleic Acids Research  vol. 46, (W1) W109-W113. 10.1093/nar/gky399
Foxler DE, Bridge KS, Foster JG, Grevitt P, Curry S, Shah KM, Davidson KM, Nagano A, Gadaleta E, Rhys HI, Kennedy PT, Hermida MA, Chang T-Y, Shaw PE, Reynolds LE, McKay TR, Wang H-W, Ribeiro PS, Plevin MJ, Lagos D, Lemoine NR, Rajan P, Graham TA, Chelala C, Hodivala-Dilke KM, Spendlove I and Sharp TV (2018). A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia. Embo Mol Med  10.15252/emmm.201708304
Wang J, Dayem Ullah AZ and Chelala C (2018). IW-Scoring: an Integrative Weighted Scoring framework for annotating and prioritizing genetic variations in the noncoding genome. Nucleic Acids Research  vol. 46, (8) 10.1093/nar/gky057
Araf S, Wang J, Korfi K, Pangault C, Kotsiou E, Rio-Machin A, Rahim T, Heward J, Clear A, Iqbal S, Davies JK, Johnson P, Calaminici M, Montoto S, Auer R, Chelala C, Gribben JG, Graham TA, Fest T, Fitzgibbon J and Okosun J (2018). Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma. Leukemia  vol. 32, (5) 1258-1263. 10.1038/s41375-018-0043-y
Fearon AE, Carter EP, Clayton NS, Wilkes EH, Baker AM, Kapitonova E, Bakhouche BA, Tanner Y, Wang J, Gadaleta E, Chelala C, Moore KM, Marshall JF, Chupin J, Schmid P, Jones JL, Lockley M, Cutillas PR and Grose RP (2018). PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer. Cell Reports  vol. 22, (9) 2469-2481. 10.1016/j.celrep.2018.02.028
WANG Y, Dayem Ullah AZ and Chelala C (2018). IW-Scoring: an Integrative Weighted Scoring framework for annotating and prioritising genetic variations in the noncoding genome. Nucleic Acids Research. Oxford University Press  Nucleic Acids Research  vol. 46, (8) e47-e47. 10.1093/nar/gky057
Gadaleta E, Pirrò S, Dayem Ullah AZ, Marzec J and Chelala C (2018). BCNTB bioinformatics: The next evolutionary step in the bioinformatics of breast cancer tissue banking. Nucleic Acids Research  vol. 46, (D1) D1055-D1061. 10.1093/nar/gkx913

2017

Wang J, Dumartin L, Mafficini A, Ulug P, Sangaralingam A, Alamiry NA, Radon TP, Salvia R, Lawlor RT, Lemoine NR, Scarpa A, Chelala C and Crnogorac-Jurcevic T (2017). Splice variants as novel targets in pancreatic ductal adenocarcinoma. Scientific Reports  vol. 7, (1) 10.1038/s41598-017-03354-z
Pearce OMT, Delaine-Smith R, Maniati E, Nichols S, Wang J, Böhm S, Rajeeve V, Ullah D, Chakravarty P, Jones RR, Montfort A, Dowe T, Gribben J, Jones JL, Kocher HM, Serody JS, Vincent BG, Connelly J, Brenton JD, Chelala C, Cutillas PR, Lockley M, Bessant C, Knight M and Balkwill FR (2017). Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers. Cancer Discov  10.1158/2159-8290.CD-17-0284
Marzec J, Dayem Ullah AZ, Pirrò S, Gadaleta E, Crnogorac-Jurcevic T, Lemoine NR, Kocher HM and Chelala C (2017). The Pancreatic Expression Database: 2018 update. Oxford University Press  Nucleic Acids Res  vol. 46, (D1) D1107-D1110. 10.1093/nar/gkx955
Sangaralingam A, Dayem Ullah AZ, Marzec J, Gadaleta E, Nagano A, Ross-Adams H, Wang J, Lemoine NR and Chelala C (2017). 'Multi-omic' data analysis using O-miner. Brief Bioinform  10.1093/bib/bbx080
Tawana K, Wang J, Király PA, Kállay K, Benyó G, Zombori M, Csomor J, Al Seraihi A, Rio-Machin A, Matolcsy A, Chelala C, Cavenagh J, Fitzgibbon J and Bödör C (2017). Recurrent somatic JAK-STAT pathway variants within a RUNX1-mutated pedigree. European Journal of Human Genetics  vol. 25, (8) 1020-1024. 10.1038/ejhg.2017.80
Morrissey B, Blyth K, Carter P, Chelala C, Jones L, Holen I and Speirs V (2017). The Sharing Experimental Animal Resources, Coordinating Holdings (SEARCH) Framework: Encouraging Reduction, Replacement, and Refinement in Animal Research. Public Library of Science  Plos Biol  vol. 15, (1) e2000719-e2000719. 10.1371/journal.pbio.2000719
Moniz LS, Surinova S, Ghazaly E, Velasco LG, Haider S, Rodríguez-Prados JC, Berenjeno IM, Chelala C and Vanhaesebroeck B (2017). Phosphoproteomic comparison of Pik3ca and Pten signalling identifies the nucleotidase NT5C as a novel AKT substrate. Scientific Reports  vol. 7, 10.1038/srep39985

2016

Makoukji J, Makhoul NJ, Khalil M, El-Sitt S, Aldin ES, Jabbour M, Boulos F, Gadaleta E, Sangaralingam A, Chelala C, Boustany RM and Tfayli A (2016). Gene expression profiling of breast cancer in Lebanese women. Nature Publishing Group: Open Access Journals - Option C  Scientific Reports  vol. 6, 36639-36639. 10.1038/srep36639
Ghayad SE, Rammal G, Ghamloush F, Basma H, Nasr R, Diab-Assaf M, Chelala C and Saab R (2016). Exosomes derived from embryonal and alveolar rhabdomyosarcoma carry differential miRNA cargo and promote invasion of recipient fibroblasts. Nature Publishing Group: Open Access Journals - Option C  Scientific Reports  vol. 6, 10.1038/srep37088
Parker H, Rose-Zerilli MJJ, Larrayoz M, Clifford R, Edelmann J, Blakemore S, Gibson J, Wang J, Ljungstrom V, Wojdacz TK, Chaplin T, Roghanian A, Davis Z, Parker A, Tausch E, Ntoufa S, Ramos S, Robbe P, Alsolami R, Steele AJ, Packham G, Rodriguez-Vicente AE, Brown L, McNicholl F, Forconi F, Pettitt A, Hillmen P, Dyer M, Cragg MS and Chelala C (2016). Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia. Leukemia  vol. 30, (11) 2179-2186. 10.1038/leu.2016.134
Speirs V, Morrisey B, Holen I, Blyth K, Carter P, Chelala C and Jones L (2016). SEARCHBreast: An online resource designed to increase the efficiency of using materials derived from breast cancer studies in animals. Wiley  Journal of Pathology  vol. 240, (1) 120-120. 10.1002/path.4755
Mao X, Luo F, Boyd LK, Zhou B, Zhang Y, Stankiewicz E, Marzec J, Vasiljevic N, Yu Y, Feng N, Xu J, Lorincz A, Jiang Y, Chelala C, Ren G, Berney DM, Zhao SC and Lu YJ (2016). NKAIN2 functions as a novel tumor suppressor in prostate cancer. Impact Journals  Oncotarget  10.18632/oncotarget.11690
Cammareri P, Rose AM, Vincent DF, Wang J, Nagano A, Libertini S, Ridgway RA, Athineos D, Coates PJ, McHugh A, Pourreyron C, Dayal JH, Larsson J, Weidlich S, Spender LC, Sapkota GP, Purdie KJ, Proby CM, Harwood CA, Leigh IM, Clevers H, Barker N, Karlsson S, Pritchard C, Marais R, Chelala C, South AP, Sansom OJ and Inman GJ (2016). Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma. Nature Publishing Group: Nature Communications  Nature Communications  vol. 7, 12493-12493. 10.1038/ncomms12493
Balarajah V, Ambily A, Dayem Ullah AZ, Imrali A, Dowe T, Al-Sarireh B, Abu Hilal M, Davidson BR, Soonawalla Z, Metcalfe M, Chin Aleong J-A, Chelala C and Kocher HM (2016). Pancreatic cancer tissue banks: where are we heading? Future Medicine Ltd  Future Oncol  vol. 12, (23) 2661-2663. 10.2217/fon-2016-0243
Locke M, Ghazaly E, Freitas MO, Mitsinga M, Lattanzio L, Lo Nigro C, Nagano A, Wang J, Chelala C, Szlosarek P and Martin SA (2016). Inhibition of the Polyamine Synthesis Pathway Is Synthetically Lethal with Loss of Argininosuccinate Synthase 1. Elsevier (Cell Press): Oaj  Cell Reports  vol. 16, (6) 1604-1613. 10.1016/j.celrep.2016.06.097
Morrissey B, Holen I, Chelala C, Carter P, Jones L, Blyth K and Speirs V (2016). Introducing SEARCHBreast: a virtual resource to facilitate sharing of surplus animal material developed for breast cancer research. Mamillan Publishing Group  Npj Breast Cancer  vol. 2, 16020-16020. 10.1038/npjbcancer.2016.20
Parker H, Rose-Zerilli MJJ, Larrayoz M, Clifford R, Edelmann J, Blakemore S, Gibson J, Wang J, Ljungström V, Wojdacz TK, Chaplin T, Roghanian A, Davis Z, Parker A, Tausch E, Ntoufa S, Ramos S, Robbe P, Alsolami R, Steele AJ, Packham G, Rodríguez-Vicente AE, Brown L, McNicholl F, Forconi F, Pettitt A, Hillmen P, Dyer M, Cragg MS and Chelala C (2016). Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia. Nature Publishing Group: Open Access Hybrid Model Option B  Leukemia  10.1038/leu.2016.134
GROSE RP, Dawkins JBN, Wang J, maniati , heward , koniali , kocher , martin , chelala , balkwill and fitzgibbon (2016). Reduced expression of histone methyltransferases KMT2C and KMT2D correlates with improved outcome in pancreatic ductal adenocarcinoma. American Association For Cancer Research  Cancer Research  10.1158/0008-5472.CAN-16-0481
Rose-Zerilli MJJ, Gibson J, Wang J, Tapper W, Davis Z, Parker H, Larrayoz M, McCarthy H, Walewska R, Forster J, Gardiner A, Steele AJ, Chelala C, Ennis S, Collins A, Oakes CC, Oscier DG and Strefford JC (2016). Longitudinal copy number, whole exome and targeted deep sequencing of 'good risk' IGHV-mutated CLL patients with progressive disease. Leukemia  vol. 30, (6) 1301-1310. 10.1038/leu.2016.10
Okosun J, Wolfson RL, Wang J, Araf S, Wilkins L, Castellano BM, Escudero-Ibarz L, Al Seraihi AF, Richter J, Bernhart SH, Efeyan A, Iqbal S, Matthews J, Clear A, Guerra-Assuncao JA, Bodor C, Quentmeier H, Mansbridge C, Johnson P, Davies A, Strefford JC, Packham G, Barrans S, Jack A, Du M-Q, Calaminici M, Lister TA, Auer R, Montoto S and Gribben JG (2016). Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma (vol 48, pg 183, 2016). Nature Genetics  vol. 48, (6) 700-700. 10.1038/ng0616-700b
Morrissey B, Blyth K, Carter P, Chelala C, Jones L, Holen I and Speirs V (2016). SEARCHBreast: A new online resource to make surplus material from in vivo models of breast cancer visible and accessible to researchers. Biomed Central  Breast Cancer Research  vol. 18, (1) 10.1186/s13058-016-0716-2
Okosun J, Wolfson RL, Wang J, Araf S, Wilkins L, Castellano BM, Escudero-Ibarz L, Seraihi AFA, Richter J, Bernhart SH, Efeyan A, Iqbal S, Matthews J, Clear A, Guerra-Assunção JA, Bödör C, Quentmeier H, Mansbridge C, Johnson P, Davies A, Strefford JC, Packham G, Barrans S, Jack A, Du M-Q, Calaminici M, Lister TA, Auer R, Montoto S and Gribben JG (2016). Corrigendum: Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma. Nat Genet  vol. 48, (6) 700-700. 10.1038/ng0616-700b
Marzec J, Mao X, Li M, Wang M, Feng N, Gou X, Wang G, Sun Z, Xu J, Xu H, Zhang X, Zhao SC, Ren G, Yu Y, Wu Y, Wu J, Xue Y, Zhou B, Zhang Y, Xu X, Li J, He W, Benlloch S, Ross-Adams H, Chen L, Hong Y, Kote-Jarai Z, Cui X and Hou J (2016). A genetic study and meta-analysis of the genetic predisposition of prostate cancer in a Chinese population. Oncotarget  vol. 7, (16) 21393-21403. 10.18632/oncotarget.7250
Blyth K, Carter P, Morrissey B, Chelala C, Jones L, Holen I and Speirs V (2016). SEARCHBreast: a new resource to locate and share surplus archival material from breast cancer animal models to help address the 3Rs. Springer Verlag (Germany)  Breast Cancer Research and Treatment  vol. 156, (3) 447-452. 10.1007/s10549-016-3785-0
Okosun J, Wolfson RL, Wang J, Araf S, Wilkins L, Castellano BM, Escudero-Ibarz L, Al Seraihi AF, Richter J, Bernhart SH, Efeyan A, Iqbal S, Matthews J, Clear A, Guerra-Assun'o JA, Bödör C, Quentmeier H, Mansbridge C, Johnson P, Davies A, Strefford JC, Packham G, Barrans S, Jack A, Du MQ, Calaminici M, Lister TA, Auer R, Montoto S and Gribben JG (2016). Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma. Nature Genetics  vol. 48, (2) 183-188. 10.1038/ng.3473

2015

Morrissey B, Blyth K, Carter P, Chelala C, Holen I, Jones L and Speirs V (2015). SEARCHBreast workshop proceedings: 3D modelling of breast cancer. Atla Alternatives to Laboratory Animals  vol. 43, (6) 367-375. 10.1177/026119291504300604
Tawana K, Wang J, Renneville A, Bödör C, Hills R, Loveday C, Savic A, Van Delft FW, Treleaven J, Georgiades P, Uglow E, Asou N, Uike N, Debeljak M, Jazbec J, Ancliff P, Gale R, Thomas X, Mialou V, Döhner K, Bullinger L, Mueller B, Pabst T, Stelljes M, Schlegelberger B, Wozniak E, Iqbal S, Okosun J, Araf S and Frank AK (2015). Disease evolution and outcomes in familial AML with germline CEBPA mutations. Blood  vol. 126, (10) 1214-1223. 10.1182/blood-2015-05-647172
Speirs V, Blyth K, Carter P, Chelala C, Holen I, Jones L and Morrissey B (2015). Animal research: Share surplus animal tissue. Nature  vol. 522, (7555) 156-156. 10.1038/522156c
Cutts RJ, Guerra-Assunção JA, Gadaleta E, Dayem Ullah AZ and Chelala C (2015). BCCTBbp: the Breast Cancer Campaign Tissue Bank bioinformatics portal. Nucleic Acids Res  vol. 43, (Database issue) D831-D836. 10.1093/nar/gku984
Smedley D, Haider S, Durinck S, Pandini L, Provero P, Allen J, Arnaiz O, Awedh MH, Baldock R, Barbiera G, Bardou P, Beck T, Blake A, Bonierbale M, Brookes AJ, Bucci G, Buetti I, Burge S, Cabau C, Carlson JW, Chelala C, Chrysostomou C, Cittaro D, Collin O, Cordova R, Cutts RJ, Dassi E, Di Genova A, Djari A and Esposito A (2015). The BioMart community portal: An innovative alternative to large, centralized data repositories. Nucleic Acids Research  vol. 43, (W1) W589-W598. 10.1093/nar/gkv350
Guillermet-Guibert J, Smith LB, Halet G, Whitehead MA, Pearce W, Rebourcet D, León K, Crépieux P, Nock G, Strömstedt M, Enerback M, Chelala C, Graupera M, Carroll J, Cosulich S, Saunders PTK, Huhtaniemi I and Vanhaesebroeck B (2015). Novel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells. Plos Genetics  vol. 11, (7) 10.1371/journal.pgen.1005304
Makoukji J, Raad M, Genadry K, El-Sitt S, Makhoul NJ, Aldin ES, Nohra E, Jabbour M, Sangaralingam A, Chelala C, Habib RH, Boulos F, Tfayli A and Boustany RM (2015). Association between CLN3 (neuronal ceroid lipofuscinosis, CLN3 type) gene expression and clinical characteristics of breast cancer patients. Frontiers in Oncology  vol. 5, (OCT) 10.3389/fonc.2015.00215
Debernardi S, Massat NJ, Radon TP, Sangaralingam A, Banissi A, Ennis DP, Dowe T, Chelala C, Pereira SP, Kocher HM, Young BD, Bond-Smith G, Hutchins R and Crnogorac-Jurcevic T (2015). Noninvasive urinary miRNA biomarkers for early detection of pancreatic adenocarcinoma. American Journal of Cancer Research  vol. 5, (11) 3455-3466.

2014

Haider S, Wang J, Nagano A, Desai A, Arumugam P, Dumartin L, Fitzgibbon J, Hagemann T, Marshall JF, Kocher HM, Crnogorac-Jurcevic T, Scarpa A, Lemoine NR and Chelala C (2014). A multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinoma. Genome Medicine  vol. 6, (12) 10.1186/s13073-014-0105-3
Ren G, Zhang Y, Mao X, Liu X, Mercer E, Marzec J, Ding D, Jiao Y, Qiu Q, Sun Y, Zhang B, Yeste-Velasco M, Chelala C, Berney D and Lu Y-J (2014). Transcription-mediated chimeric RNAs in prostate cancer: time to revisit old hypothesis? Omics  vol. 18, (10) 615-624. 10.1089/omi.2014.0042
Wong P-P, Yeoh CC, Ahmad AS, Chelala C, Gillett C, Speirs V, Jones JL and Hurst HC (2014). Identification of MAGEA antigens as causal players in the development of tamoxifen-resistant breast cancer. Oncogene  vol. 33, (37) 4579-4588. 10.1038/onc.2014.45
Moore KM, Thomas GJ, Duffy SW, Warwick J, Gabe R, Chou P, Ellis IO, Green AR, Haider S, Brouilette K, Saha A, Vallath S, Bowen R, Chelala C, Eccles D, Tapper WJ, Thompson AM, Quinlan P, Jordan L, Gillett C, Brentnall A, Violette S, Weinreb PH, Kendrew J, Barry ST, Hart IR, Jones JL and Marshall JF (2014). Therapeutic targeting of integrin αvβ6 in breast cancer. J Natl Cancer Inst  vol. 106, (8) 10.1093/jnci/dju169
Yeste-Velasco M, Mao X, Grose R, Kudahetti SC, Lin D, Marzec J, Vasiljevi N, Chaplin T, Xue L, Xu M, Foster JM, Karnam SS, James SY, Chioni A-M, Gould D, Lorincz AT, Oliver RTD, Chelala C, Thomas GM, Shipley JM, Mather SJ, Berney DM, Young BD and Lu Y-J (2014). Identification of ZDHHC14 as a novel human tumour suppressor gene. J Pathol  vol. 232, (5) 566-577. 10.1002/path.4327
Allen MD, Luong P, Hudson C, Leyton J, Delage B, Ghazaly E, Cutts R, Yuan M, Syed N, Lo Nigro C, Lattanzio L, Chmielewska-Kassassir M, Tomlinson I, Roylance R, Whitaker HC, Warren AY, Neal D, Frezza C, Beltran L, Jones LJ, Chelala C, Wu B-W, Bomalaski JS, Jackson RC, Lu Y-J, Crook T, Lemoine NR, Mather S, Foster J and Sosabowski J (2014). Prognostic and therapeutic impact of argininosuccinate synthetase 1 control in bladder cancer as monitored longitudinally by PET imaging. Cancer Res  vol. 74, (3) 896-907. 10.1158/0008-5472.CAN-13-1702
(2014). Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma. Nat Genet  vol. 46, (2) 176-181. 10.1038/ng.2856
(2014). Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma. Nature Genetics  vol. 46, (2) 176-181. 10.1038/ng.2856
Dayem Ullah AZ, Cutts RJ, Ghetia M, Gadaleta E, Hahn SA, Crnogorac-Jurcevic T, Lemoine NR and Chelala C (2014). The pancreatic expression database: recent extensions and updates. Nucleic Acids Res  vol. 42, (Database issue) D944-D949. 10.1093/nar/gkt959
Yeste-Velasco M, Mao X, Grose R, Kudahetti SC, Marzec J, Vasiljevic N, Chaplin T, Foster JM, Kamam S, Chioni A-M, Gould D, Lorincz AT, Oliver T, Chelala C, Thomas GM, Mather S, Berney D, Young BD and Lu Y-J (2014). Identification of ZDHHC14 as a novel human tumour suppressor: gene. International Journal of Molecular Medicine  vol. 34, S90-S90.
Mao X, Marzec J, Li M, Zhang Z, Feng N, Gou X, Sun Z, Xu J, Xue Y, Al Olama AA, Xu X, Li J, He W, Benlloch S, Kote-Jarai Z, Wang M, Chelala C, Easton DF, Eeles RA, Lu Y-J, Zhang H, Consortium PRACTICAL and Grp CHIPGECS (2014). Population differences in the genetic risk of prostate cancer and predisposition loci in the Chinese population. International Journal of Molecular Medicine  vol. 34, S89-S89.
Yeste-Velasco M, Mao X, Grose R, Kudahetti SC, Lin D, Marzec J, Vasiljevíc N, Chaplin T, Xue L, Xu M, Foster JM, Karnam SS, James SY, Chioni AM, Gould D, Lorincz AT, Oliver RTD, Chelala C, Thomas GM, Shipley JM, Mather SJ, Berney DM, Young BD and Lu YJ (2014). Erratum:Identification of ZDHHC14 as a novel human tumour suppressor gene. J Pathol (2014); 232: 566-577)). Journal of Pathology  vol. 234, (1) 10.1002/path.4396

2013

Speirs V, Good R, Hanby A, Matharoo-Ball B, Thomson B, Ellis I, Quinlan P, Lyons D, Coates P, Purdie C, Jordan L, Chelala C, Smith S, Ekbote U and Jones L (2013). Abstract P4-19-02: Early experience of patient donation and researcher use of tissues donated to a national breast cancer tissue bank. 10.1158/0008-5472.sabcs13-p4-19-02
Moore K, Thomas G, Duffy S, Warwick J, Gabe R, Chou P, Ellis I, Green A, Haider S, Brouilette K, Saha A, Vallath S, Bowen R, Chelala C, Eccles D, Tapper W, Thompson A, Quinlan P, Jordan L, Gillet C, Brentall A, Violette S, Weinreb P, Kendrew J, Barry S, Hart I, Jones J and Marshall J (2013). Abstract P4-15-01: Integrin avb6 is a therapeutic target for high-risk breast cancer and enhances trastuzumab efficacy. 10.1158/0008-5472.sabcs13-p4-15-01
Ene-Obong A, Clear AJ, Watt J, Wang J, Fatah R, Riches JC, Marshall JF, Chin-Aleong J, Chelala C, Gribben JG, Ramsay AG and Kocher HM (2013). Activated pancreatic stellate cells sequester CD8+ T cells to reduce their infiltration of the juxtatumoral compartment of pancreatic ductal adenocarcinoma. Gastroenterology  vol. 145, (5) 1121-1132. 10.1053/j.gastro.2013.07.025
(2013). EZH2 mutations are frequent and represent an early event in follicular lymphoma. Blood  vol. 122, (18) 3165-3168. 10.1182/blood-2013-04-496893
Moore KM, Thomas GJ, Duffy SW, Warwick J, Gabe R, Chou P, Ellis IO, Green AR, Haider S, Brouilette K, Saha A, Vallath S, Bowen R, Chelala C, Eccles D, Tapper WJ, Thompson AM, Quinlan P, Jordan L, Gillett C, Brentnall A, Violette S, Weinreb P, Kendrew J, Barry ST, Hart IR, Jones L and Marshall JF (2013). Abstract B046: Therapeutic targeting of integrin αvβ6 in high-risk breast cancer. 10.1158/1557-3125.advbc-b046
Gadaleta E, Cutts RJ, Sangaralingam A, Lemoine NR and Chelala C (2013). An Integrated Systems Approach to the Study of Pancreatic Cancer. Systems Biology in Cancer Research and Drug Discovery  10.1007/978-94-007-4819-4_4
Dayem Ullah AZ, Lemoine NR and Chelala C (2013). A practical guide for the functional annotation of genetic variations using SNPnexus. Brief Bioinform  vol. 14, (4) 437-447. 10.1093/bib/bbt004
Kadaba R, Birke H, Wang J, Hooper S, Andl CD, Di Maggio F, Soylu E, Ghallab M, Bor D, Froeling FE, Bhattacharya S, Rustgi AK, Sahai E, Chelala C, Sasieni P and Kocher HM (2013). Imbalance of desmoplastic stromal cell numbers drives aggressive cancer processes. J Pathol  vol. 230, (1) 107-117. 10.1002/path.4172
Milne R, La Vecchia C, Van Steen K, Hahn S, Buchholz M, Costello E, Esposito I, Hoheisel JD, Lange B, Lopez-Bigas N, Michalski CW, Real FX, Brand A, Malats N, LaVecchia C, Macic D, Ceric T, Iovanna J, Kleeff J, Gazouli M, Dervenis C, Hegyi P, Ruhl R, Shafat A, Sharp L, Rayan A and DeCarli A (2013). EU pancreas: An integrated european platform for pancreas cancer research - From basic science to clinical and public health interventions for a rare disease. Public Health Genomics  vol. 16, (6) 305-312. 10.1159/000355937
Barry S, Chelala C, Lines K, Sunamura M, Wang A, Marelli-Berg FM, Brennan C, Lemoine NR and Crnogorac-Jurcevic T (2013). S100P is a metastasis-associated gene that facilitates transendothelial migration of pancreatic cancer cells. Clin Exp Metastasis  vol. 30, (3) 251-264. 10.1007/s10585-012-9532-y
Crnogorac-Jurcevic T, Chelala C, Barry S, Harada T, Bhakta V, Lattimore S, Jurcevic S, Bronner M, Lemoine NR and Brentnall TA (2013). Molecular analysis of precursor lesions in familial pancreatic cancer. Plos One  vol. 8, (1) 10.1371/journal.pone.0054830

2012

Dayem Ullah AZ, Lemoine NR and Chelala C (2012). SNPnexus: a web server for functional annotation of novel and publicly known genetic variants (2012 update). Nucleic Acids Res  vol. 40, (Web Server issue) W65-W70. 10.1093/nar/gks364
Cutts RJ, Dayem Ullah AZ, Sangaralingam A, Gadaleta E, Lemoine NR and Chelala C (2012). O-miner: an integrative platform for automated analysis and mining of -omics data. Nucleic Acids Res  vol. 40, (Web Server issue) W560-W568. 10.1093/nar/gks432
Lines KE, Chelala C, Dmitrovic B, Wijesuriya N, Kocher HM, Marshall JF and Crnogorac-Jurcevic T (2012). S100P-binding protein, S100PBP, mediates adhesion through regulation of cathepsin Z in pancreatic cancer cells. Am J Pathol  vol. 180, (4) 1485-1494. 10.1016/j.ajpath.2011.12.031

2011

Froeling FEM, Feig C, Chelala C, Dobson R, Mein CE, Tuveson DA, Clevers H, Hart IR and Kocher HM (2011). Retinoic acid-induced pancreatic stellate cell quiescence reduces paracrine Wnt-β-catenin signaling to slow tumor progression. Gastroenterology  vol. 141, (4) 1486-1497.14. 10.1053/j.gastro.2011.06.047
Gadaleta E, Cutts RJ, Kelly GP, Crnogorac-Jurcevic T, Kocher HM, Lemoine NR and Chelala C (2011). A global insight into a cancer transcriptional space using pancreatic data: importance, findings and flaws. Nucleic Acids Res  vol. 39, (18) 7900-7907. 10.1093/nar/gkr533
Lines KE, Audi N, Chelala C, Wijesuriya N, Kocher H, Hurst H and Crnogorac-Jurcevic T (2011). Abstract 1537: Role of S100PBP in pancreatic adenocarcinoma. 10.1158/1538-7445.am2011-1537
Allen MD, Vaziri R, Green M, Chelala C, Brentnall AR, Dreger S, Vallath S, Nitch-Smith H, Hayward J, Carpenter R, Holliday DL, Walker RA, Hart IR and Jones JL (2011). Clinical and functional significance of α9β1 integrin expression in breast cancer: a novel cell-surface marker of the basal phenotype that promotes tumour cell invasion. J Pathol  vol. 223, (5) 646-658. 10.1002/path.2833
Cutts RJ, Gadaleta E, Lemoine NR and Chelala C (2011). Using BioMart as a framework to manage and query pancreatic cancer data. Database (Oxford)  vol. 2011, 10.1093/database/bar024
Guberman JM, Ai J, Arnaiz O, Baran J, Blake A, Baldock R, Chelala C, Croft D, Cros A, Cutts RJ, Di Génova A, Forbes S, Fujisawa T, Gadaleta E, Goodstein DM, Gundem G, Haggarty B, Haider S, Hall M, Harris T, Haw R, Hu S, Hubbard S, Hsu J, Iyer V, Jones P, Katayama T, Kinsella R, Kong L and Lawson D (2011). BioMart Central Portal: an open database network for the biological community. Database (Oxford)  vol. 2011, 10.1093/database/bar041
Gadaleta E, Lemoine NR and Chelala C (2011). Online resources of cancer data: barriers, benefits and lessons. Brief Bioinform  vol. 12, (1) 52-63. 10.1093/bib/bbq010
Cutts RJ, Gadaleta E, Hahn SA, Crnogorac-Jurcevic T, Lemoine NR and Chelala C (2011). The Pancreatic Expression database: 2011 update. Nucleic Acids Res  vol. 39, (Database issue) D1023-D1028. 10.1093/nar/gkq937

2010

Flak MB, Connell CM, Chelala C, Archibald K, Salako MA, Pirlo KJ, Lockley M, Wheatley SP, Balkwill FR and McNeish IA (2010). p21 Promotes oncolytic adenoviral activity in ovarian cancer and is a potential biomarker. Mol Cancer  vol. 9, 10.1186/1476-4598-9-175

2009

Barry S, Chelala C, Sunamura M, Bhakta V, Lemoine NR and Jurcevic T (2009). Search for Novel molecular targets in pancreatic cancer by comparative analysis of primary and metastatic disease. Clin Exp Metastas  vol. 26, (7) 856-856.
Wang Y, Gangeswaran R, Zhao X, Wang P, Tysome J, Bhakta V, Yuan M, Chikkanna-Gowda CP, Jiang G, Gao D, Cao F, Francis J, Yu J, Liu K, Yang H, Zhang Y, Zang W, Chelala C, Dong Z and Lemoine N (2009). CEACAM6 attenuates adenovirus infection by antagonizing viral trafficking in cancer cells. J Clin Invest  vol. 119, (6) 1604-1615. 10.1172/JCI37905
Chelala C, Khan A and Lemoine NR (2009). SNPnexus: a web database for functional annotation of newly discovered and public domain single nucleotide polymorphisms. Bioinformatics  vol. 25, (5) 655-661. 10.1093/bioinformatics/btn653
Harada T, Chelala C, Crnogorac-Jurcevic T and Lemoine NR (2009). Genome-wide analysis of pancreatic cancer using microarray-based techniques. Pancreatology  vol. 9, (1-2) 13-24. 10.1159/000178871
Chelala C, Lemoine NR, Hahn SA and Crnogorac-Jurcevic T (2009). A web-based platform for mining pancreatic expression datasets. Pancreatology  vol. 9, (4) 340-343. 10.1159/000212082

2008

Yuan M, Tomlinson V, Lara R, Holliday D, Chelala C, Harada T, Gangeswaran R, Manson-Bishop C, Smith P, Danovi SA, Pardo O, Crook T, Mein CA, Lemoine NR, Jones LJ and Basu S (2008). Yes-associated protein (YAP) functions as a tumor suppressor in breast. Cell Death Differ  vol. 15, (11) 1752-1759. 10.1038/cdd.2008.108
Gupta M, Raghavan M, Gale RE, Chelala C, Allen C, Molloy G, Chaplin T, Linch DC, Cazier J-B and Young BD (2008). Novel regions of acquired uniparental disomy discovered in acute myeloid leukemia. Genes Chromosomes Cancer  vol. 47, (9) 729-739. 10.1002/gcc.20573
Raghavan M, Smith L-L, Lillington DM, Chaplin T, Kakkas I, Molloy G, Chelala C, Cazier J-B, Cavenagh JD, Fitzgibbon J, Lister TA and Young BD (2008). Segmental uniparental disomy is a commonly acquired genetic event in relapsed acute myeloid leukemia. Blood  vol. 112, (3) 814-821. 10.1182/blood-2008-01-132431
Harada T, Chelala C, Bhakta V, Chaplin T, Caulee K, Baril P, Young BD and Lemoine NR (2008). Genome-wide DNA copy number analysis in pancreatic cancer using high-density single nucleotide polymorphism arrays. Oncogene  vol. 27, (13) 1951-1960. 10.1038/sj.onc.1210832

2007

Chelala C, Hahn SA, Whiteman HJ, Barry S, Hariharan D, Radon TP, Lemoine NR and Crnogorac-Jurcevic T (2007). Pancreatic Expression database: a generic model for the organization, integration and mining of complex cancer datasets. Bmc Genomics  vol. 8, 10.1186/1471-2164-8-439
Mahon PC, Baril P, Bhakta V, Chelala C, Caulee K, Harada T and Lemoine NR (2007). S100A4 contributes to the suppression of BNIP3 expression, chemoresistance, and inhibition of apoptosis in pancreatic cancer. Cancer Res  vol. 67, (14) 6786-6795. 10.1158/0008-5472.CAN-07-0440
Chelala C, Duchatelet S, Joffret M-L, Bergholdt R, Dubois-Laforgue D, Ghandil P, Pociot F, Caillat-Zucman S, Timsit J and Julier C (2007). PTPN22 R620W functional variant in type 1 diabetes and autoimmunity related traits. Diabetes  vol. 56, (2) 522-526. 10.2337/db06-0942
Harada T, Baril P, Gangeswaran R, Kelly G, Chelala C, Bhakta V, Caulee K, Mahon PC and Lemoine NR (2007). Identification of genetic alterations in pancreatic cancer by the combined use of tissue microdissection and array-based comparative genomic hybridisation. Br J Cancer  vol. 96, (2) 373-382. 10.1038/sj.bjc.6603563

2006

Senée V, Chelala C, Duchatelet S, Feng D, Blanc H, Cossec J-C, Charon C, Nicolino M, Boileau P, Cavener DR, Bougnères P, Taha D and Julier C (2006). Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism. Nat Genet  vol. 38, (6) 682-687. 10.1038/ng1802

2005

Ghandil P, Chelala C, Dubois-Laforgue D, Senee V, Caillat-Zucman S, Kockum I, Luthman H, Nerup J, Pociot F, Timsit J and Julier C (2005). Crohn's disease associated CARD15 (NOD2) variants are not involved in the susceptibility to type 1 diabetes. Mol Genet Metab  vol. 86, (3) 379-383. 10.1016/j.ymgme.2005.07.029
Chelala C and Auffray C (2005). Sex-linked recombination variation and distribution of disease-related genes. Gene  vol. 346, 29-39. 10.1016/j.gene.2004.10.019

2004

(2004). Integrative annotation of 21,037 human genes validated by full-length cDNA clones. Plos Biol  vol. 2, (6) 10.1371/journal.pbio.0020162

2002

Chelala C, Debignes MD, Imbeaud S, Zoorob R, Auffray C, Curis E, Benazeth S and Cox D (2002). Inconsistencies between maps of human chromosome 22 correlate with increased frequency of disease-related loci. J Biol Syst  vol. 10, (4) 303-317. 10.1142/S0218339002000743
Eveno E, Mariage-Samson R, Bortoli S, Imbeaud S, Decraene C, Pietu G, CHELALA C, Devignes MD and Auffray C (2002). The Genexpress IMAGE Knowledge Base of the Human Genome and Transcriptomes. Analysing Gene Expression, a Handbook of Methods: Possibilities and Pitfalls , Editors: Lorkowski S and Cullen P. Wiley-Vch 

2001

Chelala C, Imbeaud S, Devignes MD, Zoorob R and Auffray C (2001). Refined localization of twenty-one genes in subregion p13.1 of human chromosome 1. Cytogenet Cell Genet  vol. 92, (3-4) 209-212. 10.1159/000056904