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Institute of Applied Data Science

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Dr Kit Curtius

Kit Curtius

MRC Rutherford Research Fellow

Faculty of Medicine and Dentistry
Centre for Tumour Biology
020 7882 6538

www.bartscancer.london/staff/dr-kit-curtius/

Research

Gastrointestinal cancer prevention, Mathematical models of inflammatory bowel disease, Optimal cancer screening, Bioinformatics using Big Data, Stochastic modelling

Interests

My research focuses on problems in gastrointestinal cancer prevention by utilising mathematical models of inflammatory bowel disease and Barrett's oesophagus.

Our work integrates multi-scale data with mathematical modelling to understand carcinogenesis and inform cancer screening guidelines.

The aims of our current research are to use mathematical mechanistic modelling to inform optimal cancer screening recommendations, to perform patient risk stratification, and to ultimately better prognostication.

Our methodologies integrate bioinformatics using Big Data, stochastic modelling, survival analysis using public health record data, and statistical inference to address cancer prevention problems such as early detection.

Translational projects aim to elicit direct patient benefit, in part by the use and validation of web-based risk prediction tools to help clinicians and patients alike better understand cancer risk, particularly in inflammatory bowel disease (IBD). The ultimate goal is to improve precision medicine with cancer evolution theory and modelling approaches.

Publications

Publications of specific relevance to Applied Data Science

2019

Saunderson EA, Baker A-M, Williams M, Curtius K, Jones JL, Graham TA and Ficz G (2019). A novel use of random priming-based single-strand library preparation for whole genome sequencing of formalin-fixed paraffin-embedded tissue samples. Oxford University Press  Nar Genomics and Bioinformatics  vol. 2, (1) lqz017-lqz017. 10.1093/nargab/lqz017
Baker AM, Cross W, Curtius K, Al Bakir I, Choi CHR, Davis HL, Temko D, Biswas S, Martinez P, Williams MJ, Lindsay JO, Feakins R, Vega R, Hayes SJ, Tomlinson IPM, McDonald SAC, Moorghen M, Silver A, East JE, Wright NA, Wang LM, Rodriguez-Justo M, Jansen M, Hart AL, Leedham SJ and Graham TA (2019). Evolutionary history of human colitis-associated colorectal cancer. Gut  vol. 68, (6) 985-995. 10.1136/gutjnl-2018-316191

2018

Al Bakir I, Curtius K and Graham TA (2018). From Colitis to Cancer: An Evolutionary Trajectory That Merges Maths and Biology. Frontiers Media  Frontiers in Immunology  vol. 9, 2368-2368. 10.3389/fimmu.2018.02368
Curtius K, Wright NA and Graham TA (2018). An evolutionary perspective on field cancerization. Nat Rev Cancer  vol. 18, (1) 19-32. 10.1038/nrc.2017.102

2017

Curtius K, Wright NA and Graham TA (2017). Evolution of premalignant disease. Cold Spring Harbor Perspectives in Medicine  vol. 7, (12) 10.1101/cshperspect.a026542