Research

Pathway analysis of Genetic and Genomic data, Exome and Whole Genome Re-sequencing, Multi-Omics and Stratified Medicine, Trauma Injury Research, Clinical Informatics

Interests

He is an investigator at the London Farr Institute and also serves on the board and executive of eMedLab (emedlab.ac.uk), a ground breaking cloud computing facility funded by the MRC. He is also a co-investigator on several stratified medicine projects, including MRC PSORT (Psoriasis), MRC RA-Map (RA), MRC MATURA (RA) and MRC Target (Giant Cell Arteritis)

Publications

Publications of specific relevance to Applied Data Science

2020

John CR, Watson D, Barnes MR, Pitzalis C and Lewis MJ (2020). Spectrum: Fast density-aware spectral clustering for single and multi-omic data. Bioinformatics  vol. 36, (4) 1159-1166. 10.1093/bioinformatics/btz704

John CR, Watson D, Russ D, Goldmann K, Ehrenstein M, Pitzalis C, Lewis M and Barnes M (2020). M3C: Monte Carlo reference-based consensus clustering. Nature Publishing Group  Scientific Reports  vol. 10, (1) 10.1038/s41598-020-58766-1

2019

Lewis MJ, Barnes MR, Blighe K, Goldmann K, Rana S, Hackney JA, Ramamoorthi N, John CR, Watson DS, Kummerfeld SK, Hands R, Riahi S, Rocher-Ros V, Rivellese F, Humby F, Kelly S, Bombardieri M, Ng N, DiCicco M, van der Heijde D, Landewé R, van der Helm-van Mil A, Cauli A, McInnes IB, Buckley CD, Choy E, Taylor PC, Townsend MJ and Pitzalis C (2019). Molecular Portraits of Early Rheumatoid Arthritis Identify Clinical and Treatment Response Phenotypes. Cell Reports  vol. 28, 2455-2470. 10.1016/j.celrep.2019.07.091

Cabrera CP, Ng F, Nicholls HL, Gupta A, Barnes MR, Munroe PB and Caulfield MJ (2019). Over 1000 genetic loci influencing blood pressure with multiple systems and tissues implicated. Oxford University Press (Oup)  Human Molecular Genetics  vol. 28, (R2) R151-R161. 10.1093/hmg/ddz197

Mancini A, Howard SR, Cabrera CP, Barnes MR, David A, Wehkalampi K, Heger S, Lomniczi A, Guasti L, Ojeda SR and Dunkel L (2019). EAP1 regulation of GnRH promoter activity is important for human pubertal timing. Human Molecular Genetics  vol. 28, (8) 1357-1368. 10.1093/hmg/ddy451

Watson DS, Krutzinna J, Bruce IN, Griffiths CEM, McInnes IB, Barnes MR and Floridi L (2019). Clinical applications of machine learning algorithms: Beyond the black box. Bmj (Online)  vol. 364, 10.1136/bmj.l886

Foulkes AC, Watson DS, Carr DF, Kenny JG, Slidel T, Parslew R, Pirmohamed M, PSORT Consortium , Anders S, Reynolds NJ, Griffiths CEM, Warren RB and Barnes MR (2019). A Framework for Multi-Omic Prediction of Treatment Response to Biologic Therapy for Psoriasis. J Invest Dermatol  vol. 139, (1) 100-107. 10.1016/j.jid.2018.04.041

2018

Cope AP, Barnes MR, Belson A, Binks M, Brockbank S, Bonachela-Capdevila F, Carini C, Fisher BA, Goodyear CS, Emery P, Ehrenstein MR, Gozzard N, Harris R, Hollis S, Keidel S, Levesque M, Lindholm C, McDermott MF, McInnes IB, Mela CM, Parker G, Read S, Pedersen AW, Ponchel F, Porter D, Rao R, Rowe A, Schulz-Knappe P, Sleeman MA and Symmons D (2018). The RA-MAP Consortium: a working model for academia-industry collaboration. Nat Rev Rheumatol  vol. 14, (1) 53-60. 10.1038/nrrheum.2017.200

Cherlin S, Plant D, Taylor JC, Colombo M, Spiliopoulou A, Tzanis E, Morgan AW, Barnes MR, McKeigue P, Barrett JH, Pitzalis C, Barton A, Consortium MATURA and Cordell HJ (2018). Prediction of treatment response in rheumatoid arthritis patients using genome-wide SNP data. Genetic Epidemiology  vol. 42, (8) 754-771. 10.1002/gepi.22159

Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H, Ntritsos G, Dimou N, Cabrera CP, Karaman I, Ng FL, Evangelou M, Witkowska K, Tzanis E, Hellwege JN, Giri A, Velez Edwards DR, Sun YV, Cho K, Gaziano JM, Wilson PWF, Tsao PS, Kovesdy CP, Esko T, Mägi R, Milani L, Almgren P, Boutin T, Debette S and Ding J (2018). Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nat Genet  vol. 50, (12) 1755-1755. 10.1038/s41588-018-0297-3

Cabrera CP, Manson J, Shepherd JM, Torrance HD, Watson D, Longhi MP, Hoti M, Patel MB, O'Dwyer M, Nourshargh S#20399#, Pennington DJ, Barnes MR#29697# and Brohi K#22103# (2018). Correction: Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study. Plos Med  vol. 15, (10) e1002694-e1002694. 10.1371/journal.pmed.1002694

Kapil V, Rathod KS, Khambata RS, Bahra M, Velmurugan S, Purba A, S. Watson D, Barnes MR, Wade WG and Ahluwalia A (2018). Sex differences in the nitrate-nitrite-NO ^• pathway: Role of oral nitrate-reducing bacteria. Free Radical Biology and Medicine  vol. 126, 113-121. 10.1016/j.freeradbiomed.2018.07.010

Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H, Ntritsos G, Dimou N, Cabrera CP, Karaman I, Ng FL, Evangelou M, Witkowska K, Tzanis E, Hellwege JN, Giri A, Velez Edwards DR, Sun YV, Cho K, Gaziano JM, Wilson PWF, Tsao PS, Kovesdy CP, Esko T, Mägi R, Milani L, Almgren P, Boutin T, Debette S and Ding J (2018). Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nature Genetics  vol. 50, (10) 1412-1425. 10.1038/s41588-018-0205-x

Howard SR, Oleari R, Poliandri A, Chantzara V, Fantin A, Ruiz-Babot G, Metherell LA, Cabrera CP, Barnes MR, Wehkalampi K, Guasti L, Ruhrberg C, Cariboni A and Dunkel L (2018). HS6ST1 Insufficiency Causes Self-Limited Delayed Puberty in Contrast with Other GnRH Deficiency Genes. Journal of Clinical Endocrinology and Metabolism  vol. 103, (9) 3420-3429. 10.1210/jc.2018-00646

Tragante V, Hemerich D, Alshabeeb M, Brænne I, Lempiäinen H, Patel RS, den Ruijter HM, Barnes MR, Moore JH, Schunkert H, Erdmann J and Asselbergs FW (2018). Druggability of Coronary Artery Disease Risk Loci. Circ Genom Precis Med  vol. 11, (8) e001977-e001977. 10.1161/CIRCGEN.117.001977

Lewis MJ and Barnes MR (2018). RNA sequencing and machine learning as molecular scalpels. Nat Rev Rheumatol  vol. 14, (7) 388-390. 10.1038/s41584-018-0012-x

Taylor JC, Bongartz T, Massey J, Mifsud B, Spiliopoulou A, Scott IC, Wang J, Morgan M, Plant D, Colombo M, Orchard P, Twigg S, McInnes IB, Porter D, Freeston JE, Nam JL, Cordell HJ, Isaacs JD, Strathdee JL, Arnett D, de Hair MJH, Tak PP, Aslibekyan S, van Vollenhoven RF, Padyukov L, Bridges SL, Pitzalis C, Cope AP, Verstappen SMM and Emery P (2018). Genome-wide association study of response to methotrexate in early rheumatoid arthritis patients. Pharmacogenomics Journal  vol. 18, (4) 528-538. 10.1038/s41397-018-0025-5

Foulkes AC, Watson DS and Barnes MR (2018). Bioinformatics for dermatology: why we should learn about code. Br J Dermatol  vol. 178, (4) 984-984. 10.1111/bjd.16277

Bodagh N, Archbold RA, Weerackody R, Hawking MKD, Barnes MR, Lee AM, Janjuha S, Gutteridge C, Robson J and Timmis A (2018). Feasibility of real-time capture of routine clinical data in the electronic health record: a hospital-based, observational service-evaluation study. Bmj Open  vol. 8, (3) e019790-e019790. 10.1136/bmjopen-2017-019790

Howard SR#30006#, Guasti L#21441#, Poliandri A, David A, Cabrera CP, Barnes MR#29697#, Wehkalampi K, O'Rahilly S, Aiken CE, Coll AP, Ma M, Rimmington D, Yeo GSH and Dunkel L#28295# (2018). Contributions of function-Altering variants in genes implicated in pubertal timing and body mass for self-limited delayed puberty. Journal of Clinical Endocrinology and Metabolism  vol. 103, (2) 649-659. 10.1210/jc.2017-02147

2017

Hosking A, Koulouroudias M, Zemrak F, Moon JC, Rossi A, Lee A, Barnes MR, Boubertakh R, Pugliese F, Manisty C and Petersen SE (2017). Evaluation of splenic switch off in a tertiary imaging centre: validation and assessment of utility. Eur Heart J Cardiovasc Imaging  vol. 18, (11) 1216-1221. 10.1093/ehjci/jew205

Kraja AT, Cook JP, Warren HR, Surendran P, Liu C, Evangelou E, Manning AK, Grarup N, Drenos F, Sim X, Smith AV, Amin N, Blakemore AIF, Bork-Jensen J, Brandslund I, Farmaki AE, Fava C, Ferreira T, Herzig KH, Giri A, Giulianini F, Grove ML, Guo X, Harris SE, Have CT, Havulinna AS, Zhang H, Jørgensen ME, Käräjämäki AM and Kooperberg C (2017). New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals. Circulation: Cardiovascular Genetics  vol. 10, (5) 10.1161/CIRCGENETICS.117.001778

CABRERA CP, MANSON J, SHEPHERD JM#34122#, TORRANCE HD, WATSON D#37299#, LONGHI MP#31497#, HOTI M, PATEL MB, O'DWYER M#29886#, NOURSHARGH S#20399#, PENNINGTON DJ#19417#, BARNES MR#29697# and BROHI K#22103# (2017). Signatures of Inflammation and Impending Multiple Organ Dysfunction in the Hyperacute Phase of Trauma. Public Library of Science (Plos)  Plos Medicine  10.1371/journal.pmed.1002352

Sordi R, Nandra KK, Chiazza F, Johnson FL, Cabrera CP, Torrance HD, Yamada N, Patel NSA, Barnes MR, Brohi K, Collino M and Thiemermann C (2017). Artesunate Protects Against the Organ Injury and Dysfunction Induced by Severe Hemorrhage and Resuscitation. Ann Surg  vol. 265, (2) 408-417. 10.1097/SLA.0000000000001664

Cabrera CP, Manson J, Shepherd JM, Torrance HD, Watson D, Longhi MP, Hoti M, Patel MB, O Dwyer M, Nourshargh S, Pennington DJ, Barnes MR and Brohi K (2017). Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study. Plos Medicine  vol. 14, (7) 10.1371/journal.pmed.1002352

Warren HR, Evangelou E, Cabrera CP, Gao H, Ren M, Mifsud B, Ntalla I#35160#, Surendran P, Liu C, Cook JP, Kraja AT, Drenos F, Loh M, Verweij N, Marten J, Karaman I, Lepe MPS, O'Reilly PF, Knight J, Snieder H, Kato N, He J, Tai ES, Said MA, Porteous D, Alver M, Poulter N, Farrall M, Gansevoort RT and Padmanabhan S (2017). Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. Nat Genet  vol. 49, (3) 403-415. 10.1038/ng.3768

Shaked A, Chang BL, Barnes MR, Sayre P, Li YR, Asare S, DesMarais M, Holmes MV, Guettouche T and Keating BJ (2017). An ectopically expressed serum miRNA signature is prognostic, diagnostic, and biologically related to liver allograft rejection. Hepatology  vol. 65, (1) 269-280. 10.1002/hep.28786

2016

Gagliano SA, Pouget JG, Hardy J, Knight J, Barnes MR, Ryten M and Weale ME (2016). Genomics implicates adaptive and innate immunity in Alzheimer's and Parkinson's diseases. Annals of Clinical and Translational Neurology  vol. 3, (12) 924-933. 10.1002/acn3.369

Smit RA, Postmus I, Trompet S, Barnes MR, Warren H, Arsenault BJ, Chasman DI, Cupples LA, Hitman GA, Krauss RM, Li X, Psaty BM, Stein CM, Rotter JI and Jukema JW (2016). Rooted in risk: genetic predisposition for low-density lipoprotein cholesterol level associates with diminished low-density lipoprotein cholesterol response to statin treatment. Pharmacogenomics  vol. 17, (15) 1621-1628. 10.2217/pgs-2016-0091

MUNROE PB (2016). The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nature Publishing Group  Nature Genetics  10.1038/ng.3667

Postmus I, Warren HR, Trompet S, Arsenault BJ, Avery CL, Bis JC, Chasman DI, de Keyser CE, Deshmukh HA, Evans DS, Feng Q, Li X, Smit RA, Smith AV, Sun F, Taylor KD, Arnold AM, Barnes MR, Barratt BJ, Betteridge J, Boekholdt SM, Boerwinkle E, Buckley BM, Chen YI, de Craen AJ, Cummings SR, Denny JC, Dubé MP, Durrington PN and Eiriksdottir G (2016). Meta-analysis of genome-wide association studies of HDL cholesterol response to statins. Bmj Publishing Group  Journal of Medical Genetics  10.1136/jmedgenet-2016-103966

Broad J, Maurel D, Kung VWS, Hicks GA, Schemann M, Barnes MR, Kenakin TP, Granier S and Sanger GJ (2016). Human native kappa opioid receptor functions not predicted by recombinant receptors: Implications for drug design. Scientific Reports  vol. 6, 10.1038/srep30797

Jia Z, Liu Y, Guan N, Bo X, Luo Z and Barnes MR (2016). Cogena, a novel tool for co-expressed gene-set enrichment analysis, applied to drug repositioning and drug mode of action discovery. Biomed Central  Bmc Genomics  vol. 17, (1) 10.1186/s12864-016-2737-8

Narasimhan VM, Hunt KA#21075#, Mason D, Baker CL, Karczewski KJ, Barnes MR#29697#, Barnett AH, Bates C, Bellary S, Bockett NA#22041#, Giorda K, Griffiths CJ#19309#, Hemingway H, Jia Z, Kelly MA, Khawaja HA, Lek M, McCarthy S, McEachan R, O'Donnell-Luria A, Paigen K, Parisinos CA, Sheridan E, Southgate L#33488#, Tee L, Thomas M, Xue Y, Schnall-Levin M, Petkov PM and Tyler-Smith C (2016). Health and population effects of rare gene knockouts in adult humans with related parents. Science  vol. 352, (6284) 474-477. 10.1126/science.aac8624

HOWARD SR, Guasti L, Ruiz-Babot G, Mancini A, David A, Storr H, Metherell LA, Sternberg MJE, Cabrera CP, Warren H, Barnes M, Quinton R, de Roux N, Young J, Guiochon-Mantel A, Wehkalampi K, Andre V, Gothilf Y, Cariboni A and Dunkel L (2016). IGSF10 mutations dysregulate gonadotropin‐releasing hormone neuronal migration resulting in delayed puberty. Wiley  Embo Molecular Medicine  vol. 8, (6) 626-42. 10.15252/emmm.201606250

Tragante V, Braenne I, Moore JH, Barnes MR, Erdmann J and Asselbergs FW (2016). Evaluating CAD/MI loci as targets for prevention of myocardial infarction. European Journal of Clinical Investigation  vol. 46, 20-21.

Rucker JJH, Tansey KE, Rivera M, Pinto D, Cohen-Woods S, Uher R, Aitchison KJ, Craddock N, Owen MJ, Jones L, Jones I, Korszun A, Barnes MR, Preisig M, Mors O, Maier W, Rice J, Rietschel M, Holsboer F, Farmer AE, Craig IW, Scherer SW, McGuffin P and Breen G (2016). Phenotypic association analyses with copy number variation in recurrent depressive disorder. Biological Psychiatry  vol. 79, (4) 329-336. 10.1016/j.biopsych.2015.02.025

Rodriguez S, Gaunt TR, Guo Y, Zheng J, Barnes MR, Tang W, Danish F, Johnson A, Castillo BA, Li YR, Hakonarson H, Buxbaum SG, Palmer T, Tsai MY, Lange LA, Ebrahim S, Smith GD, Lawlor DA, Folsom AR, Hoogeveen R, Reiner A, Keating B and Day INM (2016). Lipids, obesity and gallbladder disease in women: Insights from genetic studies using the cardiovascular gene-centric 50K SNP array. European Journal of Human Genetics  vol. 24, (1) 106-112. 10.1038/ejhg.2015.63

2015

Griffiths CEM, Barnes MR, Burden AD, Nestle FO, Reynolds NJ, Smith CH, Warren RB and Barker JNWN (2015). Establishing an academic-industrial stratified medicine consortium: Psoriasis stratification to optimize relevant therapy. Journal of Investigative Dermatology  vol. 135, (12) 2903-2907. 10.1038/jid.2015.286

Owen HC, Torrance H#32046#, Barnes MR#29697#, Brohi K#22103#, Knight JC, Hinds CJ#21305# and O'Dwyer MJ#29886# (2015). The Role of Micrornas in The Development of Hospital Acquired Infection in Polytrauma Patients. Intensive Care Med Exp  vol. 3, (Suppl 1) 10.1186/2197-425X-3-S1-A35

Kokkinopoulos I, Ishida H, Saba R, Ruchaya P, Cabrera C, Struebig M, Barnes M, Terry A, Kaneko M, Shintani Y, Coppen S, Shiratori H, Ameen T, Mein C, Hamada H, Suzuki K and Yashiro K (2015). Single-cell expression profiling reveals a dynamic state of cardiac precursor cells in the early mouse embryo. Plos One  vol. 10, (10) 10.1371/journal.pone.0140831

Jia Z, Zhang X, Guan N, Bo X, Barnes MR and Luo Z (2015). Gene ranking of RNA-seq data via discriminant non-negative matrix factorization. Plos One  vol. 10, (9) 10.1371/journal.pone.0137782

Lanktree MB, Elbers CC, Li Y, Zhang G, Duan Q, Karczewski KJ, Guo Y, Tragante V, North KE, Cushman M, Asselbergs FW, Wilson JG, Lange LA, Drenos F, Reiner AP, Barnes MR and Keating BJ (2015). Genetic meta-analysis of 15,901 African Americans identifies variation in EXOC3L1 is associated with HDL concentration. Journal of Lipid Research  vol. 56, (9) 1781-1786. 10.1194/jlr.P059477

Gagliano SA, Ravji R, Barnes MR, Weale ME and Knight J (2015). Smoking gun or circumstantial evidence? Comparison of statistical learning methods using functional annotations for prioritizing risk variants. Scientific Reports  vol. 5, 10.1038/srep13373

Peyrot WJ, Lee SH, Milaneschi Y, Abdellaoui A, Byrne EM, Esko T, De Geus EJC, Hemani G, Hottenga JJ, Kloiber S, Levinson DF, Lucae S, Martin NG, Medland SE, Metspalu A, Milani L, Noethen MM, Potash JB, Rietschel M, Rietveld CA, Ripke S, Shi J, Willemsen G, Zhu Z, Boomsma DI, Wray NR, Penninx BWJH, Lewis CM, Hamilton SP and Weissman MM (2015). The association between lower educational attainment and depression owing to shared genetic effects? Results in ∼25 000 subjects. Molecular Psychiatry  vol. 20, (6) 735-743. 10.1038/mp.2015.50

O'Dushlaine C, Rossin L, Lee PH, Duncan L, Parikshak NN, Newhouse S, Ripke S, Neale BM, Purcell SM, Posthuma D, Nurnberger JI, Lee SH, Faraone SV, Perlis RH, Mowry BJ, Thapar A, Goddard ME, Witte JS, Absher D, Agartz I, Akil H, Amin F, Andreassen OA, Anjorin A, Anney R, Anttila V, Arking DE, Asherson P, Azevedo MH and Backlund L (2015). Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. Nature Publishing Group  Nature Neuroscience  vol. 18, (2) 199-209. 10.1038/nn.3922

Cabrera CP, Ng FL, Warren HR, Barnes MR, Munroe PB and Caulfield MJ (2015). Exploring hypertension genome-wide association studies findings and impact on pathophysiology, pathways, and pharmacogenetics. Wiley Interdisciplinary Reviews: Systems Biology and Medicine  vol. 7, (2) 73-90. 10.1002/wsbm.1290

Taylor PN, Porcu E, Chew S, Campbell PJ, Traglia M, Brown SJ, Mullin BH, Shihab HA, Min J, Walter K, Memari Y, Huang J, Barnes MR, Beilby JP, Charoen P, Danecek P, Dudbridge F, Forgetta V, Greenwood C, Grundberg E, Johnson AD, Hui J, Lim EM, McCarthy S, Muddyman D, Panicker V, Perry JRB, Bell JT, Yuan W and Relton C (2015). Whole-genome sequence-based analysis of thyroid function. Nature Communications  vol. 6, 10.1038/ncomms6681

2014

Postmus I, Trompet S, Deshmukh HA, Barnes MR, Li X, Warren HR, Chasman DI, Zhou K, Arsenault BJ, Donnelly LA, Wiggins KL, Avery CL, Griffin P, Feng Q, Taylor KD, Li G, Evans DS, Smith AV, de Keyser CE, Johnson AD, de Craen AJM, Stott DJ, Buckley BM, Ford I, Westendorp RGJ, Slagboom PE, Sattar N, Munroe PB, Sever P and Poulter N (2014). Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins. Nat Commun  vol. 5, 10.1038/ncomms6068

Marino S, Ricci B, Greco A and Acquati S (2014). A novel polycomb feed forward loop in glioblastoma multiforme. Neuro Oncol  vol. 16 Suppl 3, 10.1093/neuonc/nou206.64

Gagliano SA, Barnes MR, Weale ME and Knight J (2014). A Bayesian method to incorporate hundreds of functional characteristics with association evidence to improve variant prioritization. Plos One  vol. 9, (5) 10.1371/journal.pone.0098122

Yoneyama S, Guo Y, Lanktree MB, Barnes MR#29697#, Elbers CC, Karczewski KJ, Padmanabhan S, Bauer F, Baumert J, Beitelshees A, Berenson GS, Boer JMA, Burke G, Cade B, Chen W, Cooper-Dehoff RM, Gaunt TR, Gieger C, Gong Y, Gorski M, Heard-Costa N, Johnson T, Lamonte MJ, Mcdonough C, Monda KL, Onland-Moret NC, Nelson CP, O'Connell JR, Ordovas J and Peter I (2014). Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations. Human Molecular Genetics  vol. 23, (9) 2498-2510. 10.1093/hmg/ddt626

Tragante V, Barnes MR, Ganesh SK, Lanktree MB, Guo W, Franceschini N, Smith EN, Johnson T, Holmes MV, Padmanabhan S, Karczewski KJ, Almoguera B, Barnard J, Baumert J, Chang Y-PC, Elbers CC, Farrall M, Fischer ME, Gaunt TR, Gho JMIH, Gieger C, Goel A, Gong Y, Isaacs A, Kleber ME, Mateo Leach I, McDonough CW, Meijs MFL, Melander O and Nelson CP (2014). Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci. Am J Hum Genet  vol. 94, (3) 349-360. 10.1016/j.ajhg.2013.12.016

Voros S, Maurovich-Horvat P, Marvasty IB, Bansal AT, Barnes MR, Vazquez G, Murray SS, Voros V, Merkely B, Brown BO and Warnick GR (2014). Precision phenotyping, panomics, and system-level bioinformatics to delineate complex biologies of atherosclerosis: Rationale and design of the Genetic Loci and the Burden of Atherosclerotic Lesions study. Journal of Cardiovascular Computed Tomography  vol. 8, (6) 442-451. 10.1016/j.jcct.2014.08.006

2013

Sanseau P, Agarwal P, Barnes MR, Pastinen T, Richards JB, Cardon LR and Mooser V (2013). Rational drug repositioning by medical genetics Reply. Nature Biotechnology  vol. 31, (12) 1082-1082. 10.1038/nbt.2769

Cross-Disorder Group of the Psychiatric Genomics Consortium , Lee SH, Ripke S, Neale BM, Faraone SV, Purcell SM, Perlis RH, Mowry BJ, Thapar A, Goddard ME, Witte JS, Absher D, Agartz I, Akil H, Amin F, Andreassen OA, Anjorin A, Anney R, Anttila V, Arking DE, Asherson P, Azevedo MH, Backlund L, Badner JA, Bailey AJ, Banaschewski T, Barchas JD, Barnes MR, Barrett TB and Bass N (2013). Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet  vol. 45, (9) 984-994. 10.1038/ng.2711

Best LG, Saxena R, Anderson CM, Barnes MR, Hakonarson H, Falcon G, Martin C, Castillo BA, Karumanchi A, Keplin K, Pearson N, Lamb F, Bercier S and Keating BJ (2013). Two Variants of the C-Reactive Protein Gene Are Associated with Risk of Pre-Eclampsia in an American Indian Population. Plos One  vol. 8, (8) 10.1371/journal.pone.0071231

Munroe PB, Barnes MR and Caulfield MJ (2013). Advances in blood pressure genomics. Circ Res  vol. 112, (10) 1365-1379. 10.1161/CIRCRESAHA.112.300387

Sullivan PF, Daly MJ, Ripke S, Lewis CM, Lin D-Y, Wray NR, Neale B, Levinson DF, Breen G, Byrne EM, Rietschel M, Hoogendijk W, Hamilton SP, Weissman MM, Breuer R, Cichon S, Degenhardt F, Frank J, Gross M, Herms S, Hoefels S and Maier W (2013). A mega-analysis of genome-wide association studies for major depressive disorder. Molecular Psychiatry  vol. 18, (4) 497-511. 10.1038/mp.2012.21

Rucker JJH, Breen G, Pinto D, Pedroso I, Lewis CM, Cohen-Woods S, Uher R, Schosser A, Rivera M, Aitchison KJ, Craddock N, Owen MJ, Jones L, Jones I, Korszun A, Muglia P, Barnes MR, Preisig M, Mors O, Gill M, Maier W, Rice J, Rietschel M, Holsboer F, Farmer AE, Craig IW, Scherer SW and McGuffin P (2013). Genome-wide association analysis of copy number variation in recurrent depressive disorder. Molecular Psychiatry  vol. 18, (2) 183-189. 10.1038/mp.2011.144

2012

Pedroso I, Lourdusamy A, Rietschel M, Noethen MM, Cichon S, McGuffin P, Al-Chalabi A, Barnes MR and Breen G (2012). Common Genetic Variants and Gene-Expression Changes Associated with Bipolar Disorder Are Over-Represented in Brain Signaling Pathway Genes. Biological Psychiatry  vol. 72, (4) 311-317. 10.1016/j.biopsych.2011.12.031

Sanseau P, Agarwal P, Barnes MR, Pastinen T, Richards JB, Cardon LR and Mooser V (2012). Use of genome-wide association studies for drug repositioning. Nature Biotechnology  vol. 30, (4) 317-320. 10.1038/nbt.2151

Barnes MR (2012). An Open Innovation Ecosystem for Drug Discovery. Medchemcomm  vol. 3, (1) MCW92-MCW97. 10.1039/c1md90048j

2011

Jugurnauth SK, Chen CK, Barnes MR, Li T, Lin SK, Liu HC, Collier DA and Breen G (2011). A COMT gene haplotype associated with methamphetamine abuse. Pharmacogenetics and Genomics  vol. 21, (11) 731-740. 10.1097/FPC.0b013e32834a53f9

Barnes MR, Huxley-Jones J, Maycox PR, Lennon M, Thornber A, Kelly F, Bates S, Taylor A, Reid J, Jones N, Schroeder J, Scorer CA, Davies C, Hagan JJ, Kew JNC, Angelinetta C, Akbar T, Hirsch S, Mortimer AM, Barnes TRE and de Belleroche J (2011). Transcription and Pathway Analysis of the Superior Temporal Cortex and Anterior Prefrontal Cortex in Schizophrenia. Journal of Neuroscience Research  vol. 89, (8) 1218-1227. 10.1002/jnr.22647

Xu C-F, Reck BH, Goodman VL, Xue Z, Huang L, Barnes MR, Koshy B, Spraggs CF, Mooser VE, Cardon LR and Pandite LN (2011). Association of the hemochromatosis gene with pazopanib-induced transaminase elevation in renal cell carcinoma. Journal of Hepatology  vol. 54, (6) 1237-1243. 10.1016/j.jhep.2010.09.028

Knight J, Barnes MR, Breen G and Weale ME (2011). Using functional annotation for the Empirical determination of Bayes factors for genome-wide association study analysis. Plos One  vol. 6, (4) 10.1371/journal.pone.0014808

Dow DJ, Huxley-Jones J, Hall JM, Francks C, Maycox PR, Kew JNC, Gloger IS, Mehta NAL, Kelly FM, Muglia P, Breen G, Jugurnauth S, Pederoso I, St Clair D, Rujescu D and Barnes MR (2011). ADAMTSL3 as a candidate gene for schizophrenia: Gene sequencing and ultra-high density association analysis by imputation. Schizophrenia Research  vol. 127, (1-3) 28-34. 10.1016/j.schres.2010.12.009

2010

Lewis CM, Ng MY, Butler AW, Cohen-Woods S, Uher R, Pirlo K, Weale ME, Schosser A, Paredes UM, Rivera M, Craddock N, Owen MJ, Jones L, Jones I, Korszun A, Aitchison KJ, Shi JX, Quinn JP, MacKenzie A, Vollenweider P, Waeber G, Heath S, Lathrop M, Muglia P, Barnes MR, Whittaker JC, Tozzi F, Holsboer F, Preisig M and Farmer AE (2010). Genome-Wide Association Study of Major Recurrent Depression in the UK Population. Am J Psychiat  vol. 167, (8) 949-957. 10.1176/appi.ajp.2010.09091380

Uher R, Perroud N, Ng MYM, Hauser J, Henigsberg N, Maier W, Mors O, Placentino A, Rietschel M, Souery D, Zagar T, Czerski PM, Jerman B, Larsen ER, Schulze TG, Zobel A, Cohen-Woods S, Pirlo K, Butler AW, Muglia P, Barnes MR, Lathrop M, Farmer A, Breen G, Aitchison KJ, Craig I, Lewis CM and McGuffin P (2010). Genome-Wide Pharmacogenetics of Antidepressant Response in the GENDEP Project. American Journal of Psychiatry  vol. 167, (5) 555-564. 10.1176/appi.ajp.2009.09070932

Barnes MR and Breen G (2010). A short primer on the functional analysis of copy number variation for biomedical scientists. Methods Mol Biol  vol. 628, 119-135. 10.1007/978-1-60327-367-1_7

Barnes MR (2010). Exploring the landscape of the genome. Methods Mol Biol  vol. 628, 21-38. 10.1007/978-1-60327-367-1_2

Barnes MR (2010). Genetic variation analysis for biomedical researchers: a primer. Methods Mol Biol  vol. 628, 1-20. 10.1007/978-1-60327-367-1_1

2009

Maycox PR, Kelly F, Taylor A, Bates S, Reid J, Logendra R, Barnes MR, Larminie C, Jones N, Lennon M, Davies C, Hagan JJ, Scorer CA, Angelinetta C, Akbar T, Hirsch S, Mortimer AM, Barnes TRE and de Belleroche J (2009). Analysis of gene expression in two large schizophrenia cohorts identifies multiple changes associated with nerve terminal function. Molecular Psychiatry  vol. 14, (12) 1083-1094. 10.1038/mp.2009.18

Barnes MR, Harland L, Foord SM, Hall MD, Dix I, Thomas S, Williams-Jones BI and Brouwer CR (2009). Lowering industry firewalls: pre-competitive informatics initiatives in drug discovery. Nat Rev Drug Discov  vol. 8, (9) 701-708. 10.1038/nrd2944

Baranzini SE, Galwey NW, Wang J, Khankhanian P, Lindberg R, Pelletier D, Wu W, Uitdehaag BMJ, Kappos L, Polman CH, Matthews PM, Hauser SL, Gibson RA, Oksenberg JR, Barnes MR and Consortium G (2009). Pathway and network-based analysis of genome-wide association studies in multiple sclerosis. Human Molecular Genetics  vol. 18, (11) 2078-2090. 10.1093/hmg/ddp120

Rujescu D, Ingason A, Cichon S, Pietilainen OPH, Barnes MR, Toulopoulou T, Picchioni M, Vassos E, Ettinger U, Bramon E, Murray R, Ruggeri M, Tosato S, Bonetto C, Steinberg S, Sigurdsson E, Sigmundsson T, Petursson H, Gylfason A, Olason PI, Hardarsson G, Jonsdottir GA, Gustafsson O, Fossdal R, Giegling I, Moeller H-J, Hartmann AM, Hoffmann P, Crombie C and Fraser G (2009). Disruption of the neurexin 1 gene is associated with schizophrenia. Human Molecular Genetics  vol. 18, (5) 988-996. 10.1093/hmg/ddn351

Huxley-Jones J, Foord SM and Barnes MR (2009). Drug discovery in the extracellular matrix. International Journal of Experimental Pathology  vol. 90, (1) A80-A81.

2008

Huxley-Jones J, Foord SM and Barnes MR (2008). Drug discovery in the extracellular matrix. Drug Discov Today  vol. 13, (15-16) 685-694. 10.1016/j.drudis.2008.05.005

Bansal AT and Barnes MR (2008). Genomics in drug discovery: The best things come to those who wait. Current Opinion in Drug Discovery & Development  vol. 11, (3) 303-310.

Pettersson F, Morris AP, Barnes MR and Cardon LR (2008). Goldsurfer2 (Gs2): A comprehensive tool for the analysis and visualization of genome wide association studies. Bmc Bioinformatics  vol. 9, 10.1186/1471-2105-9-138

Zhu G, Carlsen K, Carlsen K-H, Lenney W, Silverman M, Whyte MK, Hosking L, Helms P, Roses AD, Hay DW, Barnes MR, Anderson WH and Pillai SG (2008). Polymorphisms in the endothelin-1 (EDN1) are associated with asthma in two populations. Genes and Immunity  vol. 9, (1) 23-29. 10.1038/sj.gene.6364441

Li H, Wetten S, Li L, St Jean PL, Upmanyu R, Surh L, Hosford D, Barnes MR, Briley JD, Borrie M, Coletta N, Delisle R, Dhalla D, Ehm MG, Feldman HH, Fornazzari L, Gauthier S, Goodgame N, Guzman D, Hammond S, Hollingworth P, Hsiung G-Y, Johnson J, Kelly DD, Keren R, Kertesz A, King KS, Lovestone S, Loy-English I and Matthews PM (2008). Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease. Arch Neurol  vol. 65, (1) 45-53. 10.1001/archneurol.2007.3

2007

Barnes MR, Deharo S, Grocock RJ, Brown JR and Sanseau P (2007). The micro RNA target paradigm: a fundamental and polymorphic control layer of cellular expression. Expert Opinion On Biological Therapy  vol. 7, (9) 1387-1399. 10.1517/14712598.7.9.1387

Barnes MR (2007). Integrating Genetics, Genomics and Epigenomics to Identify Disease Genes. 10.1002/9780470059180.ch9

Barnes MR (2007). Bioinformatics Challenges for the Geneticist. 10.1002/9780470059180.ch1

Barnes MR (2007). Bioinformatics for Geneticists: A Bioinformatics Primer for the Analysis of Genetic Data: Second Edition. Bioinformatics For Geneticists: a Bioinformatics Primer For The Analysis of Genetic Data: Second Edition  1-554. 10.1002/9780470059180

Southan C, Ulvsbäck M and Barnes MR (2007). A Bioinformatics Perspective on Genetics in Drug Discovery and Development. 10.1002/9780470059180.ch19

Brown JR, Deharo S, Dancis B, Barnes MR and Sanseau P (2007). Non-Coding RNA Bioinformatics. 10.1002/9780470059180.ch14

Southan C and Barnes MR (2007). Finding, Delineating and Analysing Genes. 10.1002/9780470059180.ch5

Barnes MR and Derwent PS (2007). Needle in a Haystack? Dealing with 500 000 SNP Genome Scans. 10.1002/9780470059180.ch18

Plumpton M and Barnes MR (2007). Predictive Functional Analysis of Polymorphisms: An Overview. 10.1002/9780470059180.ch11

Barnes MR (2007). Preface. Bioinformatics For Geneticists: a Bioinformatics Primer For The Analysis of Genetic Data: Second Edition  10.1002/9780470059180

Barnes MR (2007). Bioinformatics for Geneticists. John Wiley & Sons 

Teh MT, Blaydon D, Ghali LR, Briggs V, Edmunds S, Pantazi E, Barnes MR, Leigh IM, Kelsell DP and Philpott MP (2007). Erratum: Role for WNT16B in human epidermal keratinocyte proliferation and differentiation (Journal of Cell Science vol. 120 (330-339)). Journal of Cell Science  vol. 120, (5) 10.1242/jcs.03421

Teh MT, Blaydon D, Ghali LR, Edmunds S, Pantazi E, Barnes MR, Leigh IM, Kelsell DP and Philpott MP (2007). Role for WNT16B in human epidermal keratinocyte proliferation and differentiation. J Cell Sci  vol. 120, (2) 330-339. 10.1242/jcs.03329

Philpott MP, Kelsell DP, Leigh IM, TEH M, Briggs V, Pantazi E, Edmunds S, Blaydon D, Ghali LR and Barnes MR (2007). Role for WNT16B in Human Epidermal Keratinocyte Proliferation and Differentiation. Journal Cell Science  vol. 120, (2) 330-339. 10.1242/jcs.03329

2006

Barnes MR, Holbrook J, Feild JA, Searls DB and Sanseau P (2006). Risk in drug trials. Lancet  vol. 368, (9554) 2205-2205. 10.1016/S0140-6736(06)69882-6

Barnes MR (2006). Navigating the HapMap. Brief Bioinform  vol. 7, (3) 211-224. 10.1093/bib/bbl021

2005

Common JEA#21769#, Bitner-Glindzicz M, O'Toole EA#20462#, Barnes MR#29697#, Jenkins L, Forge A and Kelsell DP#20941# (2005). Specific loss of connexin 26 expression in ductal sweat gland epithelium associated with the deletion mutation del(GJB6-D13S1830). Clin Exp Dermatol  vol. 30, (6) 688-693. 10.1111/j.1365-2230.2005.01878.x

Prabhakar U, Conway TM, Murdock P, Mooney JL, Clark S, Hedge P, Bond BC, Jazwinska EC, Barnes MR, Tobin F, Damian-Iordachi V, Greller L, Hurle M, Stubbs AP, Li Z, Valoret EI, Erickson-Miller C, Cass L, Levitt B, Davis HM, Jorkasky DK and Williams WV (2005). Correlation of protein and gene expression profiles of inflammatory proteins after endotoxin challenge in human subjects. Dna and Cell Biology  vol. 24, (7) 410-431. 10.1089/dna.2005.24.410

2004

Scott BB, Zaratin PF, Clarke GD, Barnes MR, Murdock PR, Lynch FJ and Duckworth M (2004). C20orf9-003 (ACI-1), a gene localized on chromosome 20q13.12 encoding for a 49 kD cytoplasmic protein with a putative nucleotide binding site. Dna Sequence  vol. 15, (1) 1-8. 10.1080/1042517032000160200

2002

Barnes MR (2002). Psychiatric genetics in silico: databases and tools for psychiatric geneticists. Psychiatric Genetics  vol. 12, (2) 67-73. 10.1097/00041444-200206000-00003

Barnes MR (2002). SNP and mutation data on the Web - hidden treasures for uncovering. Comparative and Functional Genomics  vol. 3, (1) 67-74. 10.1002/cfg.131

Hosking LK, Boyd PR, Xu CF, Nissum M, Cantone K, Purvis IJ, Khakhar R, Barnes MR, Liberwirth U, Hagen-Mann K, Ehm MG and Riley JH (2002). Linkage disequilibrium mapping identifies a 390 kb region associated with CYP2D6 poor drug metabolising activity. Pharmacogenomics J  vol. 2, (3) 165-175. 10.1038/sj.tpj.6500096

2001

McGinnis RE, Fox H, Yates P, Cameron LA, Barnes MR, Gray IC, Spurr NK, Hurko O and St Clair D (2001). Failure to confirm NOTCH4 association with schizophrenia in a large population-based sample from Scotland. Nature Genetics  vol. 28, (2) 128-129. 10.1038/88839

2000

Fear MW, Kelsell DP, Spurr NK and Barnes MR (2000). Wnt-16a, a novel Wnt-16 isoform, which shows differential expression in adult human tissues. Biochemical and Biophysical Research Communications  vol. 278, (3) 814-820. 10.1006/bbrc.2000.3852

James IE, Kumar S, Barnes MR, Gress CJ, Hand AT, Dodds RA, Connor JR, Bradley BR, Campbell DA, Grabill SE, Williams K, Blake SM, Gowen M and Lark MW (2000). FrzB-2: a human secreted frizzled-related protein with a potential role in chondrocyte apoptosis. Osteoarthritis and Cartilage  vol. 8, (6) 452-463. 10.1053/joca.1999.0321

Sims MA, Field SD, Barnes MR, Shaikh N, Ellington K, Murphy KE, Spurr N and Campbell DA (2000). Cloning and characterisation of ITGAV, the genomic sequence for human cell adhesion protein (vitronectin) receptor alpha subunit, CD51. Cytogenetics and Cell Genetics  vol. 89, (3-4) 268-271. 10.1159/000015631

1999

Wilgoss A, Leigh IM, Barnes MR, Dopping-Hepenstal P, Eady RA, Walter JM, Kennedy CT and Kelsell DP (1999). Identification of a novel mutation R42P in the gap junction protein beta-3 associated with autosomal dominant erythrokeratoderma variabilis. J Invest Dermatol  vol. 113, (6) 1119-1122. 10.1046/j.1523-1747.1999.00792.x

Barnes MR and Russell RB (1999). A lipid-binding domain in Wnt: a case of mistaken identity? Current Biology  vol. 9, (19) R717-R718. 10.1016/S0960-9822(99)80465-5

Valdes AM, Bouzyk M, O'Brien E, Gale D, Panchal S, Barnes M#29697#, Ralston S, Reid D, Rut A and Spurr N (1999). Role of polymorphisms in parathyroid hormone receptor 1, transforming growth factor beta 1 and estrogen receptor in the genetics of osteoporosis. American Journal of Human Genetics  vol. 65, (4) A470-A470.

Valdes AM, Chamberlain JC, Bouzyk M, Panchal S, Gale D, Barnes M, Ralston SH, Reid DM, Spurr N and Rut AR (1999). Genetics of osteoporosis: Association between ESR (11q12) and ERR1 (6q25) and bone mineral density and rate of change. Journal of Bone and Mineral Research  vol. 14, S333-S333.

1998

Barnes MR, Duckworth DM and Beeley LJ (1998). Frizzled proteins constitute a novel family of G protein-coupled receptors, most closely related to the secretin family. Trends in Pharmacological Sciences  vol. 19, (10) 399-400. 10.1016/S0165-6147(98)01246-2

Hu ED, Zhu Y, Fredrickson T, Barnes M, Kelsell D, Beeley L and Brooks D (1998). Tissue restricted expression of two human Frzbs in preadipocytes and pancreas. Biochemical and Biophysical Research Communications  vol. 247, (2) 287-293. 10.1006/bbrc.1998.8784

Duetz WA, Wind B, van Andel JG, Barnes MR, Williams PA and Rutgers M (1998). Biodegradation kinetics of toluene, m-xylene, p-xylene and their intermediates through the upper TOL pathway in Pseudomonas putida (pWW0). Microbiology-Sgm  vol. 144, 1669-1675. 10.1099/00221287-144-6-1669

1997

Barnes MR, Duetz WA and Williams PA (1997). A 3-(3-hydroxyphenyl)propionic acid catabolic pathway in Rhodococcus globerulus PWD1: Cloning and characterization of the hpp operon. Journal of Bacteriology  vol. 179, (19) 6145-6153. 10.1128/jb.179.19.6145-6153.1997