Publications

Publications of specific relevance to Applied Data Science
2020

John CR, Watson D,
Barnes MR, Pitzalis C and Lewis MJ (2020).
Spectrum: Fast density-aware spectral clustering for single and multi-omic data. Bioinformatics vol. 36, (4) 1159-1166.
10.1093/bioinformatics/btz704
John CR, Watson D, Russ D, Goldmann K, Ehrenstein M, Pitzalis C, Lewis M and
Barnes M (2020).
M3C: Monte Carlo reference-based consensus clustering. Nature Publishing Group Scientific Reports vol. 10, (1)
10.1038/s41598-020-58766-12019

Lewis MJ,
Barnes MR, Blighe K, Goldmann K, Rana S, Hackney JA, Ramamoorthi N, John CR, Watson DS, Kummerfeld SK, Hands R, Riahi S, Rocher-Ros V, Rivellese F, Humby F, Kelly S, Bombardieri M, Ng N, DiCicco M, van der Heijde D, Landewé R, van der Helm-van Mil A, Cauli A, McInnes IB, Buckley CD, Choy E, Taylor PC, Townsend MJ and Pitzalis C (2019).
Molecular Portraits of Early Rheumatoid Arthritis Identify Clinical and Treatment Response Phenotypes. Cell Reports vol. 28, 2455-2470.
10.1016/j.celrep.2019.07.091
Cabrera CP, Ng F,
Nicholls HL, Gupta A,
Barnes MR, Munroe PB and Caulfield MJ (2019).
Over 1000 genetic loci influencing blood pressure with multiple systems and tissues implicated. Oxford University Press (Oup) Human Molecular Genetics vol. 28, (R2) R151-R161.
10.1093/hmg/ddz197
Mancini A, Howard SR, Cabrera CP,
Barnes MR, David A, Wehkalampi K, Heger S, Lomniczi A, Guasti L, Ojeda SR and Dunkel L (2019).
EAP1 regulation of GnRH promoter activity is important for human pubertal timing. Human Molecular Genetics vol. 28, (8) 1357-1368.
10.1093/hmg/ddy451
Watson DS, Krutzinna J, Bruce IN, Griffiths CEM, McInnes IB,
Barnes MR and Floridi L (2019).
Clinical applications of machine learning algorithms: Beyond the black box. Bmj (Online) vol. 364,
10.1136/bmj.l886
Foulkes AC, Watson DS, Carr DF, Kenny JG, Slidel T, Parslew R, Pirmohamed M, PSORT Consortium , Anders S, Reynolds NJ, Griffiths CEM, Warren RB and
Barnes MR (2019).
A Framework for Multi-Omic Prediction of Treatment Response to Biologic Therapy for Psoriasis. J Invest Dermatol vol. 139, (1) 100-107.
10.1016/j.jid.2018.04.0412018

Cope AP,
Barnes MR, Belson A, Binks M, Brockbank S, Bonachela-Capdevila F, Carini C, Fisher BA, Goodyear CS, Emery P, Ehrenstein MR, Gozzard N, Harris R, Hollis S, Keidel S, Levesque M, Lindholm C, McDermott MF, McInnes IB, Mela CM, Parker G, Read S, Pedersen AW, Ponchel F, Porter D, Rao R, Rowe A, Schulz-Knappe P, Sleeman MA and Symmons D (2018).
The RA-MAP Consortium: a working model for academia-industry collaboration. Nat Rev Rheumatol vol. 14, (1) 53-60.
10.1038/nrrheum.2017.200
Cherlin S, Plant D, Taylor JC, Colombo M, Spiliopoulou A, Tzanis E, Morgan AW,
Barnes MR, McKeigue P, Barrett JH, Pitzalis C, Barton A, Consortium MATURA and Cordell HJ (2018).
Prediction of treatment response in rheumatoid arthritis patients using genome-wide SNP data. Genetic Epidemiology vol. 42, (8) 754-771.
10.1002/gepi.22159
Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H, Ntritsos G, Dimou N, Cabrera CP, Karaman I, Ng FL, Evangelou M, Witkowska K, Tzanis E, Hellwege JN, Giri A, Velez Edwards DR, Sun YV, Cho K, Gaziano JM, Wilson PWF, Tsao PS, Kovesdy CP, Esko T, Mägi R, Milani L, Almgren P, Boutin T, Debette S and Ding J (2018).
Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nat Genet vol. 50, (12) 1755-1755.
10.1038/s41588-018-0297-3
Cabrera CP, Manson J, Shepherd JM, Torrance HD, Watson D, Longhi MP, Hoti M, Patel MB, O'Dwyer M, Nourshargh S#20399#, Pennington DJ, Barnes MR#29697# and Brohi K#22103# (2018).
Correction: Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study. Plos Med vol. 15, (10) e1002694-e1002694.
10.1371/journal.pmed.1002694
Kapil V, Rathod KS, Khambata RS, Bahra M, Velmurugan S, Purba A, S. Watson D,
Barnes MR, Wade WG and Ahluwalia A (2018).
Sex differences in the nitrate-nitrite-NO • pathway: Role of oral nitrate-reducing bacteria. Free Radical Biology and Medicine vol. 126, 113-121.
10.1016/j.freeradbiomed.2018.07.010
Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H, Ntritsos G, Dimou N, Cabrera CP, Karaman I, Ng FL, Evangelou M, Witkowska K, Tzanis E, Hellwege JN, Giri A, Velez Edwards DR, Sun YV, Cho K, Gaziano JM, Wilson PWF, Tsao PS, Kovesdy CP, Esko T, Mägi R, Milani L, Almgren P, Boutin T, Debette S and Ding J (2018).
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nature Genetics vol. 50, (10) 1412-1425.
10.1038/s41588-018-0205-x
Howard SR, Oleari R, Poliandri A, Chantzara V, Fantin A, Ruiz-Babot G, Metherell LA, Cabrera CP,
Barnes MR, Wehkalampi K, Guasti L, Ruhrberg C, Cariboni A and Dunkel L (2018).
HS6ST1 Insufficiency Causes Self-Limited Delayed Puberty in Contrast with Other GnRH Deficiency Genes. Journal of Clinical Endocrinology and Metabolism vol. 103, (9) 3420-3429.
10.1210/jc.2018-00646
Tragante V, Hemerich D, Alshabeeb M, Brænne I, Lempiäinen H, Patel RS, den Ruijter HM,
Barnes MR, Moore JH, Schunkert H, Erdmann J and Asselbergs FW (2018).
Druggability of Coronary Artery Disease Risk Loci. Circ Genom Precis Med vol. 11, (8) e001977-e001977.
10.1161/CIRCGEN.117.001977
Taylor JC, Bongartz T, Massey J, Mifsud B, Spiliopoulou A, Scott IC, Wang J, Morgan M, Plant D, Colombo M, Orchard P, Twigg S, McInnes IB, Porter D, Freeston JE, Nam JL, Cordell HJ, Isaacs JD, Strathdee JL, Arnett D, de Hair MJH, Tak PP, Aslibekyan S, van Vollenhoven RF, Padyukov L, Bridges SL, Pitzalis C, Cope AP, Verstappen SMM and Emery P (2018).
Genome-wide association study of response to methotrexate in early rheumatoid arthritis patients. Pharmacogenomics Journal vol. 18, (4) 528-538.
10.1038/s41397-018-0025-5
Foulkes AC, Watson DS and
Barnes MR (2018).
Bioinformatics for dermatology: why we should learn about code. Br J Dermatol vol. 178, (4) 984-984.
10.1111/bjd.16277
Bodagh N, Archbold RA, Weerackody R, Hawking MKD,
Barnes MR, Lee AM, Janjuha S, Gutteridge C,
Robson J and Timmis A (2018).
Feasibility of real-time capture of routine clinical data in the electronic health record: a hospital-based, observational service-evaluation study. Bmj Open vol. 8, (3) e019790-e019790.
10.1136/bmjopen-2017-019790
Howard SR#30006#, Guasti L#21441#, Poliandri A, David A, Cabrera CP, Barnes MR#29697#, Wehkalampi K, O'Rahilly S, Aiken CE, Coll AP, Ma M, Rimmington D, Yeo GSH and Dunkel L#28295# (2018).
Contributions of function-Altering variants in genes implicated in pubertal timing and body mass for self-limited delayed puberty. Journal of Clinical Endocrinology and Metabolism vol. 103, (2) 649-659.
10.1210/jc.2017-021472017

Hosking A, Koulouroudias M, Zemrak F, Moon JC, Rossi A, Lee A,
Barnes MR, Boubertakh R, Pugliese F, Manisty C and
Petersen SE (2017).
Evaluation of splenic switch off in a tertiary imaging centre: validation and assessment of utility. Eur Heart J Cardiovasc Imaging vol. 18, (11) 1216-1221.
10.1093/ehjci/jew205
Kraja AT, Cook JP, Warren HR, Surendran P, Liu C, Evangelou E, Manning AK, Grarup N, Drenos F, Sim X, Smith AV, Amin N, Blakemore AIF, Bork-Jensen J, Brandslund I, Farmaki AE, Fava C, Ferreira T, Herzig KH, Giri A, Giulianini F, Grove ML, Guo X, Harris SE, Have CT, Havulinna AS, Zhang H, Jørgensen ME, Käräjämäki AM and Kooperberg C (2017).
New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals. Circulation: Cardiovascular Genetics vol. 10, (5)
10.1161/CIRCGENETICS.117.001778
CABRERA CP, MANSON J, SHEPHERD JM#34122#, TORRANCE HD, WATSON D#37299#, LONGHI MP#31497#, HOTI M, PATEL MB, O'DWYER M#29886#, NOURSHARGH S#20399#, PENNINGTON DJ#19417#, BARNES MR#29697# and BROHI K#22103# (2017).
Signatures of Inflammation and Impending Multiple Organ Dysfunction in the Hyperacute Phase of Trauma. Public Library of Science (Plos) Plos Medicine 10.1371/journal.pmed.1002352
Sordi R, Nandra KK, Chiazza F, Johnson FL, Cabrera CP, Torrance HD, Yamada N, Patel NSA,
Barnes MR, Brohi K, Collino M and Thiemermann C (2017).
Artesunate Protects Against the Organ Injury and Dysfunction Induced by Severe Hemorrhage and Resuscitation. Ann Surg vol. 265, (2) 408-417.
10.1097/SLA.0000000000001664
Cabrera CP, Manson J, Shepherd JM, Torrance HD, Watson D, Longhi MP, Hoti M, Patel MB, O Dwyer M, Nourshargh S, Pennington DJ,
Barnes MR and Brohi K (2017).
Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study. Plos Medicine vol. 14, (7)
10.1371/journal.pmed.1002352
Warren HR, Evangelou E, Cabrera CP, Gao H, Ren M, Mifsud B, Ntalla I#35160#, Surendran P, Liu C, Cook JP, Kraja AT, Drenos F, Loh M, Verweij N, Marten J, Karaman I, Lepe MPS, O'Reilly PF, Knight J, Snieder H, Kato N, He J, Tai ES, Said MA, Porteous D, Alver M, Poulter N, Farrall M, Gansevoort RT and Padmanabhan S (2017).
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. Nat Genet vol. 49, (3) 403-415.
10.1038/ng.3768
Shaked A, Chang BL,
Barnes MR, Sayre P, Li YR, Asare S, DesMarais M, Holmes MV, Guettouche T and Keating BJ (2017).
An ectopically expressed serum miRNA signature is prognostic, diagnostic, and biologically related to liver allograft rejection. Hepatology vol. 65, (1) 269-280.
10.1002/hep.287862016

Gagliano SA, Pouget JG, Hardy J, Knight J,
Barnes MR, Ryten M and Weale ME (2016).
Genomics implicates adaptive and innate immunity in Alzheimer's and Parkinson's diseases. Annals of Clinical and Translational Neurology vol. 3, (12) 924-933.
10.1002/acn3.369
Smit RA, Postmus I, Trompet S,
Barnes MR, Warren H, Arsenault BJ, Chasman DI, Cupples LA, Hitman GA, Krauss RM, Li X, Psaty BM, Stein CM, Rotter JI and Jukema JW (2016).
Rooted in risk: genetic predisposition for low-density lipoprotein cholesterol level associates with diminished low-density lipoprotein cholesterol response to statin treatment. Pharmacogenomics vol. 17, (15) 1621-1628.
10.2217/pgs-2016-0091
MUNROE PB (2016).
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nature Publishing Group Nature Genetics 10.1038/ng.3667
Postmus I, Warren HR, Trompet S, Arsenault BJ, Avery CL, Bis JC, Chasman DI, de Keyser CE, Deshmukh HA, Evans DS, Feng Q, Li X, Smit RA, Smith AV, Sun F, Taylor KD, Arnold AM,
Barnes MR, Barratt BJ, Betteridge J, Boekholdt SM, Boerwinkle E, Buckley BM, Chen YI, de Craen AJ, Cummings SR, Denny JC, Dubé MP, Durrington PN and Eiriksdottir G (2016).
Meta-analysis of genome-wide association studies of HDL cholesterol response to statins. Bmj Publishing Group Journal of Medical Genetics 10.1136/jmedgenet-2016-103966
Broad J, Maurel D, Kung VWS, Hicks GA, Schemann M,
Barnes MR, Kenakin TP, Granier S and Sanger GJ (2016).
Human native kappa opioid receptor functions not predicted by recombinant receptors: Implications for drug design. Scientific Reports vol. 6,
10.1038/srep30797
Jia Z, Liu Y, Guan N, Bo X, Luo Z and
Barnes MR (2016).
Cogena, a novel tool for co-expressed gene-set enrichment analysis, applied to drug repositioning and drug mode of action discovery. Biomed Central Bmc Genomics vol. 17, (1)
10.1186/s12864-016-2737-8
Narasimhan VM, Hunt KA#21075#, Mason D, Baker CL, Karczewski KJ, Barnes MR#29697#, Barnett AH, Bates C, Bellary S, Bockett NA#22041#, Giorda K, Griffiths CJ#19309#, Hemingway H, Jia Z, Kelly MA, Khawaja HA, Lek M, McCarthy S, McEachan R, O'Donnell-Luria A, Paigen K, Parisinos CA, Sheridan E, Southgate L#33488#, Tee L, Thomas M, Xue Y, Schnall-Levin M, Petkov PM and Tyler-Smith C (2016).
Health and population effects of rare gene knockouts in adult humans with related parents. Science vol. 352, (6284) 474-477.
10.1126/science.aac8624
HOWARD SR, Guasti L, Ruiz-Babot G, Mancini A, David A, Storr H, Metherell LA, Sternberg MJE, Cabrera CP, Warren H,
Barnes M, Quinton R, de Roux N, Young J, Guiochon-Mantel A, Wehkalampi K, Andre V, Gothilf Y, Cariboni A and Dunkel L (2016).
IGSF10 mutations dysregulate gonadotropin‐releasing hormone neuronal migration resulting in delayed puberty. Wiley Embo Molecular Medicine vol. 8, (6) 626-42.
10.15252/emmm.201606250
Tragante V, Braenne I, Moore JH,
Barnes MR, Erdmann J and Asselbergs FW (2016).
Evaluating CAD/MI loci as targets for prevention of myocardial infarction. European Journal of Clinical Investigation vol. 46, 20-21.

Rucker JJH, Tansey KE, Rivera M, Pinto D, Cohen-Woods S, Uher R, Aitchison KJ, Craddock N, Owen MJ, Jones L, Jones I, Korszun A,
Barnes MR, Preisig M, Mors O, Maier W, Rice J, Rietschel M, Holsboer F, Farmer AE, Craig IW, Scherer SW, McGuffin P and Breen G (2016).
Phenotypic association analyses with copy number variation in recurrent depressive disorder. Biological Psychiatry vol. 79, (4) 329-336.
10.1016/j.biopsych.2015.02.025
Rodriguez S, Gaunt TR, Guo Y, Zheng J,
Barnes MR, Tang W, Danish F, Johnson A, Castillo BA, Li YR, Hakonarson H, Buxbaum SG, Palmer T, Tsai MY, Lange LA, Ebrahim S, Smith GD, Lawlor DA, Folsom AR, Hoogeveen R, Reiner A, Keating B and Day INM (2016).
Lipids, obesity and gallbladder disease in women: Insights from genetic studies using the cardiovascular gene-centric 50K SNP array. European Journal of Human Genetics vol. 24, (1) 106-112.
10.1038/ejhg.2015.632015

Griffiths CEM,
Barnes MR, Burden AD, Nestle FO, Reynolds NJ, Smith CH, Warren RB and Barker JNWN (2015).
Establishing an academic-industrial stratified medicine consortium: Psoriasis stratification to optimize relevant therapy. Journal of Investigative Dermatology vol. 135, (12) 2903-2907.
10.1038/jid.2015.286
Owen HC, Torrance H#32046#, Barnes MR#29697#, Brohi K#22103#, Knight JC, Hinds CJ#21305# and O'Dwyer MJ#29886# (2015).
The Role of Micrornas in The Development of Hospital Acquired Infection in Polytrauma Patients. Intensive Care Med Exp vol. 3, (Suppl 1)
10.1186/2197-425X-3-S1-A35
Kokkinopoulos I, Ishida H, Saba R, Ruchaya P, Cabrera C, Struebig M,
Barnes M, Terry A, Kaneko M, Shintani Y, Coppen S, Shiratori H, Ameen T, Mein C, Hamada H, Suzuki K and Yashiro K (2015).
Single-cell expression profiling reveals a dynamic state of cardiac precursor cells in the early mouse embryo. Plos One vol. 10, (10)
10.1371/journal.pone.0140831
Jia Z, Zhang X, Guan N, Bo X,
Barnes MR and Luo Z (2015).
Gene ranking of RNA-seq data via discriminant non-negative matrix factorization. Plos One vol. 10, (9)
10.1371/journal.pone.0137782
Lanktree MB, Elbers CC, Li Y, Zhang G, Duan Q, Karczewski KJ, Guo Y, Tragante V, North KE, Cushman M, Asselbergs FW, Wilson JG, Lange LA, Drenos F, Reiner AP,
Barnes MR and Keating BJ (2015).
Genetic meta-analysis of 15,901 African Americans identifies variation in EXOC3L1 is associated with HDL concentration. Journal of Lipid Research vol. 56, (9) 1781-1786.
10.1194/jlr.P059477
Gagliano SA, Ravji R,
Barnes MR, Weale ME and Knight J (2015).
Smoking gun or circumstantial evidence? Comparison of statistical learning methods using functional annotations for prioritizing risk variants. Scientific Reports vol. 5,
10.1038/srep13373
Peyrot WJ, Lee SH, Milaneschi Y, Abdellaoui A, Byrne EM, Esko T, De Geus EJC, Hemani G, Hottenga JJ, Kloiber S, Levinson DF, Lucae S, Martin NG, Medland SE, Metspalu A, Milani L, Noethen MM, Potash JB, Rietschel M, Rietveld CA, Ripke S, Shi J, Willemsen G, Zhu Z, Boomsma DI, Wray NR, Penninx BWJH, Lewis CM, Hamilton SP and Weissman MM (2015).
The association between lower educational attainment and depression owing to shared genetic effects? Results in ∼25 000 subjects. Molecular Psychiatry vol. 20, (6) 735-743.
10.1038/mp.2015.50
O'Dushlaine C, Rossin L, Lee PH, Duncan L, Parikshak NN, Newhouse S, Ripke S, Neale BM, Purcell SM, Posthuma D, Nurnberger JI, Lee SH, Faraone SV, Perlis RH, Mowry BJ, Thapar A, Goddard ME, Witte JS, Absher D, Agartz I, Akil H, Amin F, Andreassen OA, Anjorin A, Anney R, Anttila V, Arking DE, Asherson P, Azevedo MH and Backlund L (2015).
Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. Nature Publishing Group Nature Neuroscience vol. 18, (2) 199-209.
10.1038/nn.3922
Cabrera CP, Ng FL, Warren HR,
Barnes MR, Munroe PB and Caulfield MJ (2015).
Exploring hypertension genome-wide association studies findings and impact on pathophysiology, pathways, and pharmacogenetics. Wiley Interdisciplinary Reviews: Systems Biology and Medicine vol. 7, (2) 73-90.
10.1002/wsbm.1290
Taylor PN, Porcu E, Chew S, Campbell PJ, Traglia M, Brown SJ, Mullin BH, Shihab HA, Min J, Walter K, Memari Y, Huang J,
Barnes MR, Beilby JP, Charoen P, Danecek P, Dudbridge F, Forgetta V, Greenwood C, Grundberg E, Johnson AD, Hui J, Lim EM, McCarthy S, Muddyman D, Panicker V, Perry JRB, Bell JT, Yuan W and Relton C (2015).
Whole-genome sequence-based analysis of thyroid function. Nature Communications vol. 6,
10.1038/ncomms66812014

Postmus I, Trompet S, Deshmukh HA,
Barnes MR, Li X, Warren HR, Chasman DI, Zhou K, Arsenault BJ, Donnelly LA, Wiggins KL, Avery CL, Griffin P, Feng Q, Taylor KD, Li G, Evans DS, Smith AV, de Keyser CE, Johnson AD, de Craen AJM, Stott DJ, Buckley BM, Ford I, Westendorp RGJ, Slagboom PE, Sattar N, Munroe PB, Sever P and Poulter N (2014).
Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins. Nat Commun vol. 5,
10.1038/ncomms6068
Marino S, Ricci B, Greco A and Acquati S (2014).
A novel polycomb feed forward loop in glioblastoma multiforme. Neuro Oncol vol. 16 Suppl 3,
10.1093/neuonc/nou206.64
Gagliano SA,
Barnes MR, Weale ME and Knight J (2014).
A Bayesian method to incorporate hundreds of functional characteristics with association evidence to improve variant prioritization. Plos One vol. 9, (5)
10.1371/journal.pone.0098122
Yoneyama S, Guo Y, Lanktree MB, Barnes MR#29697#, Elbers CC, Karczewski KJ, Padmanabhan S, Bauer F, Baumert J, Beitelshees A, Berenson GS, Boer JMA, Burke G, Cade B, Chen W, Cooper-Dehoff RM, Gaunt TR, Gieger C, Gong Y, Gorski M, Heard-Costa N, Johnson T, Lamonte MJ, Mcdonough C, Monda KL, Onland-Moret NC, Nelson CP, O'Connell JR, Ordovas J and Peter I (2014).
Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations. Human Molecular Genetics vol. 23, (9) 2498-2510.
10.1093/hmg/ddt626
Tragante V,
Barnes MR, Ganesh SK, Lanktree MB, Guo W, Franceschini N, Smith EN, Johnson T, Holmes MV, Padmanabhan S, Karczewski KJ, Almoguera B, Barnard J, Baumert J, Chang Y-PC, Elbers CC, Farrall M, Fischer ME, Gaunt TR, Gho JMIH, Gieger C, Goel A, Gong Y, Isaacs A, Kleber ME, Mateo Leach I, McDonough CW, Meijs MFL, Melander O and Nelson CP (2014).
Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci. Am J Hum Genet vol. 94, (3) 349-360.
10.1016/j.ajhg.2013.12.016
Voros S, Maurovich-Horvat P, Marvasty IB, Bansal AT,
Barnes MR, Vazquez G, Murray SS, Voros V, Merkely B, Brown BO and Warnick GR (2014).
Precision phenotyping, panomics, and system-level bioinformatics to delineate complex biologies of atherosclerosis: Rationale and design of the Genetic Loci and the Burden of Atherosclerotic Lesions study. Journal of Cardiovascular Computed Tomography vol. 8, (6) 442-451.
10.1016/j.jcct.2014.08.0062013

Sanseau P, Agarwal P,
Barnes MR, Pastinen T, Richards JB, Cardon LR and Mooser V (2013).
Rational drug repositioning by medical genetics Reply. Nature Biotechnology vol. 31, (12) 1082-1082.
10.1038/nbt.2769
Cross-Disorder Group of the Psychiatric Genomics Consortium , Lee SH, Ripke S, Neale BM, Faraone SV, Purcell SM, Perlis RH, Mowry BJ, Thapar A, Goddard ME, Witte JS, Absher D, Agartz I, Akil H, Amin F, Andreassen OA, Anjorin A, Anney R, Anttila V, Arking DE, Asherson P, Azevedo MH, Backlund L, Badner JA, Bailey AJ, Banaschewski T, Barchas JD,
Barnes MR, Barrett TB and Bass N (2013).
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet vol. 45, (9) 984-994.
10.1038/ng.2711
Best LG, Saxena R, Anderson CM,
Barnes MR, Hakonarson H, Falcon G, Martin C, Castillo BA, Karumanchi A, Keplin K, Pearson N, Lamb F, Bercier S and Keating BJ (2013).
Two Variants of the C-Reactive Protein Gene Are Associated with Risk of Pre-Eclampsia in an American Indian Population. Plos One vol. 8, (8)
10.1371/journal.pone.0071231
Sullivan PF, Daly MJ, Ripke S, Lewis CM, Lin D-Y, Wray NR, Neale B, Levinson DF, Breen G, Byrne EM, Rietschel M, Hoogendijk W, Hamilton SP, Weissman MM, Breuer R, Cichon S, Degenhardt F, Frank J, Gross M, Herms S, Hoefels S and Maier W (2013).
A mega-analysis of genome-wide association studies for major depressive disorder. Molecular Psychiatry vol. 18, (4) 497-511.
10.1038/mp.2012.21
Rucker JJH, Breen G, Pinto D, Pedroso I, Lewis CM, Cohen-Woods S, Uher R, Schosser A, Rivera M, Aitchison KJ, Craddock N, Owen MJ, Jones L, Jones I, Korszun A, Muglia P,
Barnes MR, Preisig M, Mors O, Gill M, Maier W, Rice J, Rietschel M, Holsboer F, Farmer AE, Craig IW, Scherer SW and McGuffin P (2013).
Genome-wide association analysis of copy number variation in recurrent depressive disorder. Molecular Psychiatry vol. 18, (2) 183-189.
10.1038/mp.2011.1442012

Pedroso I, Lourdusamy A, Rietschel M, Noethen MM, Cichon S, McGuffin P, Al-Chalabi A,
Barnes MR and Breen G (2012).
Common Genetic Variants and Gene-Expression Changes Associated with Bipolar Disorder Are Over-Represented in Brain Signaling Pathway Genes. Biological Psychiatry vol. 72, (4) 311-317.
10.1016/j.biopsych.2011.12.031
Sanseau P, Agarwal P,
Barnes MR, Pastinen T, Richards JB, Cardon LR and Mooser V (2012).
Use of genome-wide association studies for drug repositioning. Nature Biotechnology vol. 30, (4) 317-320.
10.1038/nbt.21512011

Jugurnauth SK, Chen CK,
Barnes MR, Li T, Lin SK, Liu HC, Collier DA and Breen G (2011).
A COMT gene haplotype associated with methamphetamine abuse. Pharmacogenetics and Genomics vol. 21, (11) 731-740.
10.1097/FPC.0b013e32834a53f9
Barnes MR, Huxley-Jones J, Maycox PR, Lennon M, Thornber A, Kelly F, Bates S, Taylor A, Reid J, Jones N, Schroeder J, Scorer CA, Davies C, Hagan JJ, Kew JNC, Angelinetta C, Akbar T, Hirsch S, Mortimer AM, Barnes TRE and de Belleroche J (2011).
Transcription and Pathway Analysis of the Superior Temporal Cortex and Anterior Prefrontal Cortex in Schizophrenia. Journal of Neuroscience Research vol. 89, (8) 1218-1227.
10.1002/jnr.22647
Xu C-F, Reck BH, Goodman VL, Xue Z, Huang L,
Barnes MR, Koshy B, Spraggs CF, Mooser VE, Cardon LR and Pandite LN (2011).
Association of the hemochromatosis gene with pazopanib-induced transaminase elevation in renal cell carcinoma. Journal of Hepatology vol. 54, (6) 1237-1243.
10.1016/j.jhep.2010.09.028
Knight J,
Barnes MR, Breen G and Weale ME (2011).
Using functional annotation for the Empirical determination of Bayes factors for genome-wide association study analysis. Plos One vol. 6, (4)
10.1371/journal.pone.0014808
Dow DJ, Huxley-Jones J, Hall JM, Francks C, Maycox PR, Kew JNC, Gloger IS, Mehta NAL, Kelly FM, Muglia P, Breen G, Jugurnauth S, Pederoso I, St Clair D, Rujescu D and
Barnes MR (2011).
ADAMTSL3 as a candidate gene for schizophrenia: Gene sequencing and ultra-high density association analysis by imputation. Schizophrenia Research vol. 127, (1-3) 28-34.
10.1016/j.schres.2010.12.0092010

Lewis CM, Ng MY, Butler AW, Cohen-Woods S, Uher R, Pirlo K, Weale ME, Schosser A, Paredes UM, Rivera M, Craddock N, Owen MJ, Jones L, Jones I, Korszun A, Aitchison KJ, Shi JX, Quinn JP, MacKenzie A, Vollenweider P, Waeber G, Heath S, Lathrop M, Muglia P,
Barnes MR, Whittaker JC, Tozzi F, Holsboer F, Preisig M and Farmer AE (2010).
Genome-Wide Association Study of Major Recurrent Depression in the UK Population. Am J Psychiat vol. 167, (8) 949-957.
10.1176/appi.ajp.2010.09091380
Uher R, Perroud N, Ng MYM, Hauser J, Henigsberg N, Maier W, Mors O, Placentino A, Rietschel M, Souery D, Zagar T, Czerski PM, Jerman B, Larsen ER, Schulze TG, Zobel A, Cohen-Woods S, Pirlo K, Butler AW, Muglia P,
Barnes MR, Lathrop M, Farmer A, Breen G, Aitchison KJ, Craig I, Lewis CM and McGuffin P (2010).
Genome-Wide Pharmacogenetics of Antidepressant Response in the GENDEP Project. American Journal of Psychiatry vol. 167, (5) 555-564.
10.1176/appi.ajp.2009.09070932
Barnes MR and Breen G (2010).
A short primer on the functional analysis of copy number variation for biomedical scientists. Methods Mol Biol vol. 628, 119-135.
10.1007/978-1-60327-367-1_72009

Maycox PR, Kelly F, Taylor A, Bates S, Reid J, Logendra R,
Barnes MR, Larminie C, Jones N, Lennon M, Davies C, Hagan JJ, Scorer CA, Angelinetta C, Akbar T, Hirsch S, Mortimer AM, Barnes TRE and de Belleroche J (2009).
Analysis of gene expression in two large schizophrenia cohorts identifies multiple changes associated with nerve terminal function. Molecular Psychiatry vol. 14, (12) 1083-1094.
10.1038/mp.2009.18
Barnes MR, Harland L, Foord SM, Hall MD, Dix I, Thomas S, Williams-Jones BI and Brouwer CR (2009).
Lowering industry firewalls: pre-competitive informatics initiatives in drug discovery. Nat Rev Drug Discov vol. 8, (9) 701-708.
10.1038/nrd2944
Baranzini SE, Galwey NW, Wang J, Khankhanian P, Lindberg R, Pelletier D, Wu W, Uitdehaag BMJ, Kappos L, Polman CH, Matthews PM, Hauser SL, Gibson RA, Oksenberg JR,
Barnes MR and Consortium G (2009).
Pathway and network-based analysis of genome-wide association studies in multiple sclerosis. Human Molecular Genetics vol. 18, (11) 2078-2090.
10.1093/hmg/ddp120
Rujescu D, Ingason A, Cichon S, Pietilainen OPH,
Barnes MR, Toulopoulou T, Picchioni M, Vassos E, Ettinger U, Bramon E, Murray R, Ruggeri M, Tosato S, Bonetto C, Steinberg S, Sigurdsson E, Sigmundsson T, Petursson H, Gylfason A, Olason PI, Hardarsson G, Jonsdottir GA, Gustafsson O, Fossdal R, Giegling I, Moeller H-J, Hartmann AM, Hoffmann P, Crombie C and Fraser G (2009).
Disruption of the neurexin 1 gene is associated with schizophrenia. Human Molecular Genetics vol. 18, (5) 988-996.
10.1093/hmg/ddn351
Huxley-Jones J, Foord SM and
Barnes MR (2009).
Drug discovery in the extracellular matrix. International Journal of Experimental Pathology vol. 90, (1) A80-A81.
2008

Bansal AT and
Barnes MR (2008).
Genomics in drug discovery: The best things come to those who wait. Current Opinion in Drug Discovery & Development vol. 11, (3) 303-310.

Pettersson F, Morris AP,
Barnes MR and Cardon LR (2008).
Goldsurfer2 (Gs2): A comprehensive tool for the analysis and visualization of genome wide association studies. Bmc Bioinformatics vol. 9,
10.1186/1471-2105-9-138
Zhu G, Carlsen K, Carlsen K-H, Lenney W, Silverman M, Whyte MK, Hosking L, Helms P, Roses AD, Hay DW,
Barnes MR, Anderson WH and Pillai SG (2008).
Polymorphisms in the endothelin-1 (EDN1) are associated with asthma in two populations. Genes and Immunity vol. 9, (1) 23-29.
10.1038/sj.gene.6364441
Li H, Wetten S, Li L, St Jean PL, Upmanyu R, Surh L, Hosford D,
Barnes MR, Briley JD, Borrie M, Coletta N, Delisle R, Dhalla D, Ehm MG, Feldman HH, Fornazzari L, Gauthier S, Goodgame N, Guzman D, Hammond S, Hollingworth P, Hsiung G-Y, Johnson J, Kelly DD, Keren R, Kertesz A, King KS, Lovestone S, Loy-English I and Matthews PM (2008).
Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease. Arch Neurol vol. 65, (1) 45-53.
10.1001/archneurol.2007.32007
Barnes MR, Deharo S, Grocock RJ, Brown JR and Sanseau P (2007).
The micro RNA target paradigm: a fundamental and polymorphic control layer of cellular expression. Expert Opinion On Biological Therapy vol. 7, (9) 1387-1399.
10.1517/14712598.7.9.1387
Barnes MR (2007).
Bioinformatics for Geneticists: A Bioinformatics Primer for the Analysis of Genetic Data: Second Edition. Bioinformatics For Geneticists: a Bioinformatics Primer For The Analysis of Genetic Data: Second Edition 1-554.
10.1002/9780470059180
Barnes MR (2007).
Preface. Bioinformatics For Geneticists: a Bioinformatics Primer For The Analysis of Genetic Data: Second Edition 10.1002/9780470059180
Barnes MR (2007).
Bioinformatics for Geneticists. John Wiley & Sons 
Teh MT, Blaydon D, Ghali LR, Briggs V, Edmunds S, Pantazi E,
Barnes MR, Leigh IM, Kelsell DP and Philpott MP (2007).
Erratum: Role for WNT16B in human epidermal keratinocyte proliferation and differentiation (Journal of Cell Science vol. 120 (330-339)). Journal of Cell Science vol. 120, (5)
10.1242/jcs.03421
Teh MT, Blaydon D, Ghali LR, Edmunds S, Pantazi E,
Barnes MR, Leigh IM, Kelsell DP and Philpott MP (2007).
Role for WNT16B in human epidermal keratinocyte proliferation and differentiation. J Cell Sci vol. 120, (2) 330-339.
10.1242/jcs.03329
Philpott MP, Kelsell DP, Leigh IM, TEH M, Briggs V, Pantazi E, Edmunds S, Blaydon D, Ghali LR and
Barnes MR (2007).
Role for WNT16B in Human Epidermal Keratinocyte Proliferation and Differentiation. Journal Cell Science vol. 120, (2) 330-339.
10.1242/jcs.033292006
2005

Common JEA#21769#, Bitner-Glindzicz M, O'Toole EA#20462#, Barnes MR#29697#, Jenkins L, Forge A and Kelsell DP#20941# (2005).
Specific loss of connexin 26 expression in ductal sweat gland epithelium associated with the deletion mutation del(GJB6-D13S1830). Clin Exp Dermatol vol. 30, (6) 688-693.
10.1111/j.1365-2230.2005.01878.x
Prabhakar U, Conway TM, Murdock P, Mooney JL, Clark S, Hedge P, Bond BC, Jazwinska EC,
Barnes MR, Tobin F, Damian-Iordachi V, Greller L, Hurle M, Stubbs AP, Li Z, Valoret EI, Erickson-Miller C, Cass L, Levitt B, Davis HM, Jorkasky DK and Williams WV (2005).
Correlation of protein and gene expression profiles of inflammatory proteins after endotoxin challenge in human subjects. Dna and Cell Biology vol. 24, (7) 410-431.
10.1089/dna.2005.24.4102004

Scott BB, Zaratin PF, Clarke GD,
Barnes MR, Murdock PR, Lynch FJ and Duckworth M (2004).
C20orf9-003 (ACI-1), a gene localized on chromosome 20q13.12 encoding for a 49 kD cytoplasmic protein with a putative nucleotide binding site. Dna Sequence vol. 15, (1) 1-8.
10.1080/10425170320001602002002
Barnes MR (2002).
SNP and mutation data on the Web - hidden treasures for uncovering. Comparative and Functional Genomics vol. 3, (1) 67-74.
10.1002/cfg.131
Hosking LK, Boyd PR, Xu CF, Nissum M, Cantone K, Purvis IJ, Khakhar R,
Barnes MR, Liberwirth U, Hagen-Mann K, Ehm MG and Riley JH (2002).
Linkage disequilibrium mapping identifies a 390 kb region associated with CYP2D6 poor drug metabolising activity. Pharmacogenomics J vol. 2, (3) 165-175.
10.1038/sj.tpj.65000962001

McGinnis RE, Fox H, Yates P, Cameron LA,
Barnes MR, Gray IC, Spurr NK, Hurko O and St Clair D (2001).
Failure to confirm NOTCH4 association with schizophrenia in a large population-based sample from Scotland. Nature Genetics vol. 28, (2) 128-129.
10.1038/888392000

Fear MW, Kelsell DP, Spurr NK and
Barnes MR (2000).
Wnt-16a, a novel Wnt-16 isoform, which shows differential expression in adult human tissues. Biochemical and Biophysical Research Communications vol. 278, (3) 814-820.
10.1006/bbrc.2000.3852
James IE, Kumar S,
Barnes MR, Gress CJ, Hand AT, Dodds RA, Connor JR, Bradley BR, Campbell DA, Grabill SE, Williams K, Blake SM, Gowen M and Lark MW (2000).
FrzB-2: a human secreted frizzled-related protein with a potential role in chondrocyte apoptosis. Osteoarthritis and Cartilage vol. 8, (6) 452-463.
10.1053/joca.1999.0321
Sims MA, Field SD,
Barnes MR, Shaikh N, Ellington K, Murphy KE, Spurr N and Campbell DA (2000).
Cloning and characterisation of ITGAV, the genomic sequence for human cell adhesion protein (vitronectin) receptor alpha subunit, CD51. Cytogenetics and Cell Genetics vol. 89, (3-4) 268-271.
10.1159/0000156311999

Wilgoss A, Leigh IM,
Barnes MR, Dopping-Hepenstal P, Eady RA, Walter JM, Kennedy CT and Kelsell DP (1999).
Identification of a novel mutation R42P in the gap junction protein beta-3 associated with autosomal dominant erythrokeratoderma variabilis. J Invest Dermatol vol. 113, (6) 1119-1122.
10.1046/j.1523-1747.1999.00792.x
Valdes AM, Bouzyk M, O'Brien E, Gale D, Panchal S, Barnes M#29697#, Ralston S, Reid D, Rut A and Spurr N (1999).
Role of polymorphisms in parathyroid hormone receptor 1, transforming growth factor beta 1 and estrogen receptor in the genetics of osteoporosis. American Journal of Human Genetics vol. 65, (4) A470-A470.

Valdes AM, Chamberlain JC, Bouzyk M, Panchal S, Gale D,
Barnes M, Ralston SH, Reid DM, Spurr N and Rut AR (1999).
Genetics of osteoporosis: Association between ESR (11q12) and ERR1 (6q25) and bone mineral density and rate of change. Journal of Bone and Mineral Research vol. 14, S333-S333.
1998
Barnes MR, Duckworth DM and Beeley LJ (1998).
Frizzled proteins constitute a novel family of G protein-coupled receptors, most closely related to the secretin family. Trends in Pharmacological Sciences vol. 19, (10) 399-400.
10.1016/S0165-6147(98)01246-2
Hu ED, Zhu Y, Fredrickson T,
Barnes M, Kelsell D, Beeley L and Brooks D (1998).
Tissue restricted expression of two human Frzbs in preadipocytes and pancreas. Biochemical and Biophysical Research Communications vol. 247, (2) 287-293.
10.1006/bbrc.1998.8784
Duetz WA, Wind B, van Andel JG,
Barnes MR, Williams PA and Rutgers M (1998).
Biodegradation kinetics of toluene, m-xylene, p-xylene and their intermediates through the upper TOL pathway in Pseudomonas putida (pWW0). Microbiology-Sgm vol. 144, 1669-1675.
10.1099/00221287-144-6-16691997
Barnes MR, Duetz WA and Williams PA (1997).
A 3-(3-hydroxyphenyl)propionic acid catabolic pathway in Rhodococcus globerulus PWD1: Cloning and characterization of the hpp operon. Journal of Bacteriology vol. 179, (19) 6145-6153.
10.1128/jb.179.19.6145-6153.1997