Publications

Publications of specific relevance to Applied Data Science
2020

Thompson JE, Sridhar AN, Shaw G, Rajan P,
Rajan P, Mohammed A, Briggs TP, Nathan S, Kelly JD and Sooriakumaran P (2020).
Peri-operative, functional and early oncologic outcomes of salvage robotic-assisted radical prostatectomy after high-intensity focused ultrasound partial ablation. Bmc Urology vol. 20, (1)
10.1186/s12894-020-00656-9
Lauria A, Peirone S, Giudice MD, Priante F,
Rajan P, Caselle M, Oliviero S and Cereda M (2020).
Identification of altered biological processes in heterogeneous RNA-sequencing data by discretization of expression profiles. Nucleic Acids Research vol. 48, (4) 1730-1747.
10.1093/nar/gkz1208
Xu L, Mao X, Grey A, Scandura G, Guo T, Burke E, Marzec J, Abdu S, Stankiewicz E, Davies CR,
Rajan P, Tipples K, Hines J, Chan PY, Campbell D, Wilkinson K, Kudahetti S, Shamash J, Oliver T, Berney D, Shaw G and Lu YJ (2020).
Reply by Authors. The Journal of Urology vol. 203, (1) 81-82.
10.1097/01.JU.0000602796.11621.76
Sehmbi AS, Sridhar AN, Sahadevan K, Rai BP, Nwangwu P, Mohammed A, Freeman A, Mottrie A, Olsson MJ, Wiklund NP, Nathan MS, Briggs TP, Kelly JD and
Rajan P (2020).
Early outcomes of robot-assisted radical prostatectomy following completion of a structured training curriculum: a single surgeon cohort study. Journal of Clinical Urology 10.1177/20514158209381762019

De Laere B, Crippa A, Ghysel C, Ost P,
Rajan P, Eklund M, Dirix L, Grönberg H and Lindberg J (2019).
106PElevated driver mutational burden or number of perturbed pathways and poor response to abiraterone or enzalutamide in metastatic castration-resistant prostate cancer. Annals of Oncology vol. 30, (Supplement_5) v30-v31.
10.1093/annonc/mdz239.017
Xu L, Mao X, Grey A, Scandura G, Guo T, Burke E, Marzec J, Abdu S, Stankiewicz E, Davies CR,
Rajan P, Tipples K, Hines J, Chan PY, Campbell D, Wilkinson K, Kudahetti S, Shamash J, Oliver T, Berney D, Shaw G and Lu Y-J (2019).
Noninvasive Detection of Clinically Significant Prostate Cancer Using Circulating Tumor Cells. The Journal of Urology vol. 203, 101097JU000-101097JU000.
10.1097/JU.0000000000000475
Thompson JE, Sridhar AN, Tan WS, Freeman A, Haider A, Allen C, Moore CM, Orczyk C, Mazzon G, Khetrapal P, Shaw G,
Rajan P, Mohammed A, Briggs TP, Nathan S, Kelly JD and Sooriakumaran P (2019).
Pathological Findings and Magnetic Resonance Imaging Concordance at Salvage Radical Prostatectomy for Local Recurrence following Partial Ablation Using High Intensity Focused Ultrasound. J Urol vol. 201, (6) 1134-1143.
10.1097/JU.0000000000000135
De Laere B,
Rajan P, Grönberg H, Dirix L, Lindberg J and CORE-ARV-CTC and ProBIO Investigators (2019).
Androgen Receptor Burden and Poor Response to Abiraterone or Enzalutamide in TP53 Wild-Type Metastatic Castration-Resistant Prostate Cancer. Jama Oncol 10.1001/jamaoncol.2019.0869
Heavey S, Costa H, Pye H, Burt EC, Jenkinson S, Lewis GR, Bosshard-Carter L, Watson F, Jameson C, Ratynska M, Ben-Salha I, Haider A, Johnston EW, Feber A, Shaw G, Sridhar A, Nathan S,
Rajan P, Briggs TP, Sooriakumaran P, Kelly JD, Freeman A and Whitaker HC (2019).
PEOPLE: PatiEnt prOstate samPLes for rEsearch, a tissue collection pathway utilizing magnetic resonance imaging data to target tumor and benign tissue in fresh radical prostatectomy specimens. Prostate vol. 79, (7) 768-777.
10.1002/pros.23782
De Laere B, Oeyen S, Mayrhofer M, Whitington T, van Dam PJ, Van Oyen P, Ghysel C, Ampe J, Ost P, Demey W, Hoekx L, Schrijvers D, Brouwers B, Lybaert W, Everaert EG, De Maeseneer D, Strijbos M, Bols A, Fransis K, Beije N, de Kruijff IE, van Dam V, Brouwer A, Goossens D, Heyrman L, Van den Eynden GG, Rutten A, Favero JD, Rantalainen M and
Rajan P (2019).
TP53 outperforms other androgen receptor biomarkers to predict abiraterone or enzalutamide outcome in metastatic castration-resistant prostate cancer. Clinical Cancer Research vol. 25, (6) 1766-1773.
10.1158/1078-0432.CCR-18-19432018

Mayrhofer M, De Laere B, Whitington T, Van Oyen P, Ghysel C, Ampe J, Ost P, Demey W, Hoekx L, Schrijvers D, Brouwers B, Lybaert W, Everaert E, De Maeseneer D, Strijbos M, Bols A, Fransis K, Oeyen S, Van Dam PJ, Van Den Eynden G, Rutten A, Aly M, Nordström T, Van Laere S, Rantalainen M,
Rajan P, Egevad L, Ullén A, Yachnin J and Dirix L (2018).
Cell-free DNA profiling of metastatic prostate cancer reveals microsatellite instability, structural rearrangements and clonal hematopoiesis. Genome Medicine vol. 10, (1)
10.1186/s13073-018-0595-5
Munkley J, Maia TM, Ibarluzea N, Livermore KE, Vodak D, Ehrmann I, James K,
Rajan P, Barbosa-Morais NL and Elliott DJ (2018).
Androgen-dependent alternative mRNA isoform expression in prostate cancer cells. F1000 Research Ltd F1000research vol. 7, 1189-1189.
10.12688/f1000research.15604.1
Foxler DE, Bridge KS, Foster JG, Grevitt P, Curry S, Shah KM, Davidson KM, Nagano A, Gadaleta E, Rhys HI, Kennedy PT, Hermida MA, Chang T-Y, Shaw PE, Reynolds LE, McKay TR, Wang H-W, Ribeiro PS, Plevin MJ, Lagos D, Lemoine NR,
Rajan P,
Graham TA,
Chelala C, Hodivala-Dilke KM, Spendlove I and Sharp TV (2018).
A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia. Embo Mol Med 10.15252/emmm.201708304
Rajan P, Hagman A, Sooriakumaran P, Nyberg T, Wallerstedt A, Adding C, Akre O, Carlsson S, Hosseini A, Olsson M, Egevad L, Wiklund F, Steineck G and Wiklund NP (2018).
Oncologic Outcomes After Robot-assisted Radical Prostatectomy: A Large European Single-centre Cohort with Median 10-Year Follow-up. European Urology Focus vol. 4, (3) 351-359.
10.1016/j.euf.2016.10.0072017
Rajan P, Sooriakumaran P, Nyberg T, Akre O, Carlsson S, Egevad L, Steineck G and Wiklund NP (2017).
Effect of Comorbidity on Prostate Cancer-Specific Mortality: A Prospective Observational Study. J Clin Oncol vol. 35, (31) 3566-3574.
10.1200/JCO.2016.70.7794
Munkley J, Livermore K,
Rajan P and Elliott DJ (2017).
RNA splicing and splicing regulator changes in prostate cancer pathology. Human Genetics vol. 136, (9) 1143-1154.
10.1007/s00439-017-1792-9
Munkley J, McClurg UL, Livermore KE, Ehrmann I, Knight B, Mccullagh P, Mcgrath J, Crundwell M, Harries LW, Leung HY, Mills IG, Robson CN,
Rajan P and Elliott DJ (2017).
The cancer-associated cell migration protein TSPAN1 is under control of androgens and its upregulation increases prostate cancer cell migration. Macmillan Publishers Limited, Part of Springer Nature Sci Rep vol. 7, (1) 5249-5249.
10.1038/s41598-017-05489-52016

Munkley J, Vodak D, Livermore KE, James K, Wilson BT, Knight B, Mccullagh P, Mcgrath J, Crundwell M, Harries LW, Leung HY, Robson CN, Mills IG,
Rajan P and Elliott DJ (2016).
Glycosylation is an Androgen-Regulated Process Essential for Prostate Cancer Cell Viability. Elsevier: Creative Commons Ebiomedicine 10.1016/j.ebiom.2016.04.0182015

Stockley J, Markert E, Zhou Y, Robson CN, Elliott DJ, Lindberg J, Leung HY and
Rajan P (2015).
The RNA-binding protein Sam68 regulates expression and transcription function of the androgen receptor splice variant AR-V7. Sci Rep vol. 5,
10.1038/srep13426
Rajan P, Frew JA, Wilson JM, Azzabi AST, McMenemin RM, Stockley J, Soomro NA, Durkan G, Pedley ID and Leung HY (2015).
Feasibility study of a randomized controlled trial comparing docetaxel chemotherapy and androgen deprivation therapy with sequential prostatic biopsies from patients with advanced non-castration-resistant prostate cancer. Urol Oncol vol. 33, (8) 337.e1-337.e6.
10.1016/j.urolonc.2015.05.012
Munkley J, Lafferty NP, Kalna G, Robson CN, Leung HY,
Rajan P and Elliott DJ (2015).
Androgen-regulation of the protein tyrosine phosphatase PTPRR activates ERK1/2 signalling in prostate cancer cells. Bmc Cancer vol. 15,
10.1186/s12885-015-1012-8
Munkley J, Oltean S, Vodák D, Wilson BT, Livermore KE, Zhou Y, Star E, Floros VI, Johannessen B, Knight B, McCullagh P, McGrath J, Crundwell M, Skotheim RI, Robson CN, Leung HY, Harries LW,
Rajan P, Mills IG and Elliott DJ (2015).
The androgen receptor controls expression of the cancerassociated sTn antigen and cell adhesion through induction of ST6GalNAc1 in prostate cancer. Oncotarget vol. 6, (33) 34358-34374.
10.18632/oncotarget.6024
Munkley J, Livermore KE, McClurg UL, Kalna G, Knight B, McCullagh P, McGrath J, Crundwell M, Leung HY, Robson CN, Harries LW,
Rajan P and Elliott DJ (2015).
The PI3K regulatory subunit gene PIK3R1 is under direct control of androgens and repressed in prostate cancer cells. Oncoscience vol. 2, (9) 755-764.
10.18632/oncoscience.2432014
Rajan P, Stockley J, Sudbery IM, Fleming JT, Hedley A, Kalna G, Sims D, Ponting CP, Heger A, Robson CN, McMenemin RM, Pedley ID and Leung HY (2014).
Identification of a candidate prognostic gene signature by transcriptome analysis of matched pre- and post-treatment prostatic biopsies from patients with advanced prostate cancer. Bmc Cancer vol. 14,
10.1186/1471-2407-14-977
Rajan P, Sudbery IM, Villasevil MEM, Mui E, Fleming J, Davis M, Ahmad I, Edwards J, Sansom OJ, Sims D, Ponting CP, Heger A, McMenemin RM, Pedley ID and Leung HY (2014).
Next-generation sequencing of advanced prostate cancer treated with androgen-deprivation therapy. Eur Urol vol. 66, (1) 32-39.
10.1016/j.eururo.2013.08.011
Munkley J,
Rajan P, Lafferty NP, Dalgliesh C, Jackson RM, Robson CN, Leung HY and Elliott DJ (2014).
A novel androgen-regulated isoform of the TSC2 tumour suppressor gene increases cell proliferation. Oncotarget vol. 5, (1) 131-139.
10.18632/oncotarget.1405
Stockley J, Villasevil MEM, Nixon C, Ahmad I, Leung HY and
Rajan P (2014).
The RNA-binding protein hnRNPA2 regulates β-catenin protein expression and is overexpressed in prostate cancer. Rna Biol vol. 11, (6) 755-765.
10.4161/rna.288002008
Rajan P, Gaughan L, Dalgliesh C, El-Sherif A, Robson CN, Leung HY and Elliott DJ (2008).
The RNA-binding and adaptor protein Sam68 modulates signal-dependent splicing and transcriptional activity of the androgen receptor. J Pathol vol. 215, (1) 67-77.
10.1002/path.2324