Research

Interests

The Draviam Lab is  directed by Viji M. Draviam, Professor of Quantitative Cell and Molecular Biology at the School of Biological and Chemical Sciences, Queen Mary. Regulated sub-cellular movements are a fundamental aspect of all living cells and they rely on precisely controlled force generation mechanisms. How forces are imparted, monitored and corrected in response to heterogeneous biochemical and physical cues is a fascinating and challenging biological problem. The lab addresses these fundamental questions in the context of dividing human cells and apply the molecular knowledge on force generation and cell division to accelerate cytoskeletal drug discovery and drug resistance biomarker research.

Publications

Publications of specific relevance to Applied Data Science

2019

Conti D, Gul P, Islam A, Martín-Durán JM, Pickersgill RW and Draviam VM (2019). Kinetochores attached to microtubule-ends are stabilised by astrin bound pp1 to ensure proper chromosome segregation. Elife Sciences Publications Ltd  Elife  vol. 8, 10.7554/eLife.49325

Hart M, Zulkipli I, Shrestha RL, Dang D, Conti D, Gul P, Kujawiak I and Draviam VM (2019). MARK2/Par1b kinase present at centrosomes and retraction fibres corrects spindle off-centring induced by actin disassembly. The Royal Society  Open Biology  vol. 9, (6) 10.1098/rsob.180263

2018

Zulkipli I, Clark J, HART M, Shrestha R, GUL P, DANG D, Kasichiwin T, Kujawiak I, SASTRY N and DRAVIAM VM (2018). Spindle rotation in human cells is reliant on a MARK2-mediated equatorial spindle centering mechanism. Rockefeller University Press  Journal of Cell Biology  10.1083/jcb.201804166

2017

Shrestha RL, Conti D, Tamura N, Braun D, Ramalingam RA, Cieslinski K, Ries J and Draviam VM (2017). Aurora-B kinase pathway controls the lateral to end-on conversion of kinetochore-microtubule attachments in human cells. Macmillan Publishers Limited, Part of Springer Nature.  Nat Commun  vol. 8, (1) 150-150. 10.1038/s41467-017-00209-z

2016

Hiroi N, Draviam VM and Funahashi A (2016). Editorial: Quantitative Biology: Dynamics of Living Systems. Frontiers Media Sa  Front Physiol  vol. 7, 10.3389/fphys.2016.00196

Patel H, Stavrou I, Shrestha RL, Draviam V, Frame MC and Brunton VG (2016). Kindlin1 regulates microtubule function to ensure normal mitosis. Journal of Molecular Cell Biology  vol. 8, (4) 338-348. 10.1093/jmcb/mjw009

2015

Iorio F, Shrestha RL, Levin N, Boilot V, Garnett MJ, Saez-Rodriguez J and Draviam VM (2015). A semi-supervised approach for refining transcriptional signatures of drug response and repositioning predictions. Plos One  vol. 10, (10) 10.1371/journal.pone.0139446

Corrigan AM, Shrestha R, Draviam VM and Donald AM (2015). Modeling of Noisy Spindle Dynamics Reveals Separable Contributions to Achieving Correct Orientation. Biophysical Journal  vol. 109, (7) 1398-1409. 10.1016/j.bpj.2015.08.014

Tamura N, Simon JE, Nayak A, Shenoy R, Hiroi N, Boilot V, Funahashi A and Draviam VM (2015). A proteomic study of mitotic phase-Specific interactors of EB1 reveals a role for SXIP-Mediated protein interactions in anaphase onset. Biology Open  vol. 4, (2) 155-169. 10.1242/bio.201410413

Ochi T, Blackford AN, Coates J, Jhujh S, Mehmood S, Tamura N, Travers J, Wu Q, Draviam VM, Robinson CV, Blundell TL and Jackson SP (2015). PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair. Science  vol. 347, (6218) 185-188. 10.1126/science.1261971

Nakai Y, Ozeki M, Hiraiwa T, Tanimoto R, Funahashi A, Hiroi N, Taniguchi A, Nonaka S, Boilot V, Shrestha R, Clark J, Tamura N, Draviam VM and Oku H (2015). High-speed microscopy with an electrically tunable lens to image the dynamics of in vivo molecular complexes. Review of Scientific Instruments  vol. 86, (1) 10.1063/1.4905330

2014

Shrestha RL, Tamura N, Fries A, Levin N, Clark J and Draviam VM (2014). TAO1 kinase maintains chromosomal stability by facilitating proper congression of chromosomes. Open Biology  vol. 4, (JUNE) 10.1098/rsob.130108

Chin-Hui-Men S, Nandra K, Clark J and Draviam VM (2014). Need for multi-scale systems to identify spindle orientation regulators relevant to tissue disorganisation in solid cancers. Frontiers in Physiology  vol. 5 JUL, 10.3389/fphys.2014.00278

2013

Shrestha RL and Draviam VM (2013). Erratum: Lateral to end-on conversion of chromosome-microtubule attachment requires kinesins CENP-E and MCAK (Current Biology (2013) 23 (1514-1526)). Current Biology  vol. 23, (23) 2440-2441. 10.1016/j.cub.2013.11.015

Shrestha RL and Draviam VM (2013). Lateral to end-on conversion of chromosome-microtubule attachment requires kinesins cenp-e and MCAK. Current Biology  vol. 23, (16) 1514-1526. 10.1016/j.cub.2013.06.040

Corrigan AM, Shrestha RL, Zulkipli I, Hiroi N, Liu Y, Tamura N, Yang B, Patel J, Funahashi A, Donald A and Draviam VM (2013). Automated tracking of mitotic spindle pole positions shows that LGN is required for spindle rotation but not orientation maintenance. Cell Cycle  vol. 12, (16) 2643-2655. 10.4161/cc.25671

Draviam VM, Funahashi A, Hiroi N, Kimura A and Kobayashi TJ (2013). Meeting report of the international workshop on quantitative biology 2012: Mesoscopic and microscopic worlds meet. Frontiers in Physiology  vol. 3 JAN, 10.3389/fphys.2012.00479

2012

Tamura N and Draviam VM (2012). Microtubule plus-ends within a mitotic cell are 'moving platforms' with anchoring, signalling and force-coupling roles. Open Biology  vol. 2, (NOV) 10.1098/rsob.120132

2009

Pagliuca C, Draviam VM, Marco E, Sorger PK and De Wulf P (2009). Roles for the conserved Spc105p/Kre28p complex in kinetochore-microtubule binding and the spindle assembly checkpoint. Plos One  vol. 4, (10) 10.1371/journal.pone.0007640

McAinsh AD, Meraldi P, Draviam VM, Toso A and Sorger PK (2009). The human kinetochore proteins Nnf1R and Mcm21R are required for accurate chromosome segregation (The EMBO Journal (2006) 25 (4033-4049) DOI:10.1038/sj.emboj.7601293). Embo Journal  vol. 28, (9) 10.1038/emboj.2009.94

2008

Foijer F, Draviam VM and Sorger PK (2008). Studying chromosome instability in the mouse. Biochimica Et Biophysica Acta - Reviews On Cancer  vol. 1786, (1) 73-82. 10.1016/j.bbcan.2008.07.004

2007

Stegmeier F, Rape M, Draviam VM, Nalepa G, Sowa ME, Ang XL, McDonald ER, Li MZ, Hannon GJ, Sorger PK, Kirschner MW, Harper JW and Elledge SJ (2007). Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature  vol. 447, (7141) 876-881.

Draviam VM, Stegmeier F, Nalepa G, Sowa ME, Chen J, Liang A, Hannon GJ, Sorger PK, Harper JW and Elledge SJ (2007). A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling. Nature Cell Biology  vol. 9, (5) 556-564. 10.1038/ncb1569

Stegmeier F, Rape M, Draviam VM, Nalepa G, Sowa ME, Ang XL, McDonald ER, Li MZ, Hannon GJ, Sorger PK, Kirschner MW, Harper JW and Elledge SJ (2007). Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature  vol. 446, (7138) 876-881. 10.1038/nature05694

Basto R, Gergely F, Draviam VM, Ohkura H, Liley K and Raff JW (2007). Hsp90 is required to localise cyclin B and Msps/ch-TOG to the mitotic spindle in Drosophila and humans. Journal of Cell Science  vol. 120, (7) 1278-1287. 10.1242/jcs.000604

2006

McAinsh AD, Meraldi P, Draviam VM, Toso A and Sorger PK (2006). The human kinetochore proteins Nnf1R and Mcm21R are required for accurate chromosome segregation. Embo Journal  vol. 25, (17) 4033-4049. 10.1038/sj.emboj.7601293

Draviam VM, Shapiro I, Aldridge B and Sorger PK (2006). Misorientation and reduced stretching of aligned sister kinetochores promote chromosome missegregation in EB1- or APC-depleted cells. Embo Journal  vol. 25, (12) 2814-2827. 10.1038/sj.emboj.7601168

2004

Meraldi P, Draviam VM and Sorger PK (2004). Timing and checkpoints in the regulation of mitotic progression. Developmental Cell  vol. 7, (1) 45-60. 10.1016/j.devcel.2004.06.006

Draviam VM, Xie S and Sorger PK (2004). Chromosome segregation and genomic stability. Current Opinion in Genetics and Development  vol. 14, (2) 120-125. 10.1016/j.gde.2004.02.007

2003

Gergely F, Draviam VM and Raff JW (2003). The ch-TOG/XMAP215 protein is essential for spindle pole organization in human somatic cells. Genes and Development  vol. 17, (3) 336-341. 10.1101/gad.245603

2001

Draviam VM, Orrechia S, Lowe M, Pardi R and Pines J (2001). The localization of human cyclins B1 and B2 determines CDK1 substrate specificity and neither enzyme requires MEK to disassemble the Golgi apparatus. Journal of Cell Biology  vol. 152, (5) 945-958. 10.1083/jcb.152.5.945

Grants

Grants of specific relevance to Applied Data Science

Protecting chromosome number: how cells establish, monitor and maintain chromosome-microtubule interaction?
Draviam VM
£394,990 Biotechnology and Biological Sciences Research Council (30-04-2018 - 29-04-2021)

Summary

Aneuploidy mechanisms
Draviam Sastry VM
Cancer Research UK (01-08-2008 - 31-07-2015)

Summary